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Heparin-azithromycin microparticles show anti-inflammatory effects and inhibit SARS-CoV-2 and bacterial pathogens associated to lung infections.
Carbohydr Polym
January 2025
Pharmaceutics and Food Technology Department, Faculty of Pharmacy, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain; Instituto Universitario de Farmacia Industrial, Faculty of Pharmacy, Universidad Complutense de Madrid, 28040 Madrid, Spain. Electronic address:
Pulmonary infections are a leading cause of morbidity and mortality worldwide, a situation exacerbated by the COVID-19. Azithromycin (AZM) is used orally to treat pulmonary infections due to its ability to accumulate in lung tissues and immune cells after oral administration. Sulfated polysaccharides, such as heparin, are known to inhibit SARS-CoV-2 entry.
View Article and Find Full Text PDFThe Role of Mast Cells in the Remodeling Effects of Molecular Hydrogen on the Lung Local Tissue Microenvironment under Simulated Pulmonary Hypertension.
Int J Mol Sci
October 2024
RUDN University, 6 Miklukho-Maklaya St, 117198 Moscow, Russia.
Molecular hydrogen (H) has antioxidant, anti-inflammatory, and anti-fibrotic effects. In a rat model simulating pulmonary fibrotic changes induced by monocrotaline-induced pulmonary hypertension (MPH), we had previously explored the impact of inhaled H on lung inflammation and blood pressure. In this study, we further focused the biological effects of H on mast cells (MCs) and the parameters of the fibrotic phenotype of the local tissue microenvironment.
View Article and Find Full Text PDF"To BAL or not to BAL, that is the question": Variations in smoke inhalation injury guidelines from burn units and centres in England, Scotland and Wales.
Burns
December 2024
Department of Burns and Plastic Surgery, Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust, United Kingdom. Electronic address:
Aim: To evaluate variations in diagnostic criteria and management recommendations for smoke inhalation injury (SII) amongst the burn networks of England, Scotland, and Wales.
Methods: A descriptive cross-sectional study examining SII guidelines provided by adult burn units and centres in England, Scotland and Wales.
Results: All 16 adult burn units and centres responded.
A case of the effective inhalation of nitric oxide therapy for caused severe pulmonary hypertension with protamine neutralization of systemic heparinization during totally endoscopic minimally invasive cardiac surgery.
J Extra Corpor Technol
September 2024
Department of Clinical Engineering, Kitaharima Medical Center, 926-250, Ichiba-cho, Ono-shi, Hyogo 675-1392, Japan.
Severe pulmonary vasoconstriction induced by protamine is a rare complication. We report a case of a 77-year-old male patient with a history of mitral valve plasty (MVP). He underwent redo MVP via right thoracotomy under the totally endoscopic procedure (MICS redo-MVP).
View Article and Find Full Text PDFInhalable nanoparticles with enhanced cuproptosis and cGAS-STING activation for synergistic lung metastasis immunotherapy.
Acta Pharm Sin B
August 2024
Department of Pharmaceutics, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Cheelloo College of Medicine, Shandong University, Jinan 250012, China.
Article Synopsis
- The study addresses the limitations of cuproptosis in treating lung metastasis due to low copper accumulation and an immunosuppressive tumor environment.
- An inhalable nanodevice (CLDCu) is designed to enhance cuproptosis by efficiently delivering copper and disulfiram directly to lung lesions, significantly increasing drug accumulation compared to traditional intravenous methods.
- CLDCu not only promotes cuproptosis in tumor cells but also activates the STING pathway to enhance immune response, leading to improved antitumor immunity when combined with anti-PD-L1 therapy.
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