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Background: The β-secretase-1 inhibitors (BACEi), including verubecestat, were extensively studied in prodromal to moderate AD and demonstrated early cognitive decline (negative effect) at doses achieving >50% inhibition of amyloid production. Questions remain as to whether BACEi may still have utility, if used earlier in disease and at lower levels of inhibition. A mechanistic model of the progression of Alzheimer's disease was used to predict effects of alternative BACEi therapeutic approaches on disease progression.
View Article and Find Full Text PDFAchieving theranostic probes targeting BRD3/BRD4 for imaging and therapy of tumor.
Eur J Med Chem
February 2025
Department of Medicinal Chemistry, School of Pharmacy, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China. Electronic address:
The BET family proteins play pleiotropic roles in the tumorigenesis and growth of various human malignancies that have aroused great interests as the cancer therapeutic targets. Therefore, it's significant to develop labeling toolkits for the dynamic monitoring of BET family proteins in living tumor cells and tissue slices. In particular, there are few small-molecule fluorescent probes based on BET family proteins developed for real-time imaging of these proteins in tumor cells and tissues and treatment of breast cancer.
View Article and Find Full Text PDFA randomized clinical trial evaluating Hydralazine's efficacy in early-stage Alzheimer's disease: The EHSAN Study.
Sci Rep
November 2024
Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Alzheimer's Disease (AD), a neurodegenerative disorder escalating worldwide, remains incurable with existing interventions merely mitigating symptoms. Hydralazine, an antihypertensive agent, has displayed neuroprotective potential in AD animal models via amplification of mitochondrial functionality and stimulation of stress management and repair pathways. Nevertheless, its effectiveness and tolerability in human AD cohorts are yet to be confirmed.
View Article and Find Full Text PDF[Update on the diagnosis and treatment of dysmenorrhoea].
Semergen
October 2024
Servicio de Obstetricia y Ginecología, Complexo Hospitalario Universitario de Ourense, Ourense, España. Electronic address:
Article Synopsis
- * Proper diagnosis involves a thorough medical history, including details about pain and menstrual cycles, while ultrasound is only necessary if pelvic issues are suspected.
- * Treatment options include pain relief with Paracetamol or NSAIDs and hormonal contraceptives, and a new law now allows for temporary disability benefits for those suffering from severe dysmenorrhea.
Water-soluble AIE photosensitizer in short-wave infrared region for albumin-enhanced and self-reporting phototheranostics.
Biomaterials
March 2025
Department of Chemistry, and Department of Chemical and Biological Engineering, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, 999077, PR China; School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong, 518172, PR China. Electronic address:
Organic photosensitizers (PSs) play important roles in phototheranostics, and contribute to the fast development of precision medicine. However, water-soluble and highly emissive organic PSs, especially those emitting in the short-wave infrared region (SWIR), are still challenging. Also, it's difficult to prepare self-reporting PSs for visualizing the treatment via stimulated emission depletion (STED) nanoscopy.
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