Objective: To clone the human genomic DNA of augmenter of liver regeneration (ALR) and specify the intron-exon structure.
Methods: Using human ALR cDNA sequence as a reference and BLAST path as a nucleotide homology search tool, GenBank has been searched for ALR homologous genomic DNA sequence. The intron-exon sequences were defined by the Breathnath-Chambon rule.
Results: The coding sequence of human ALR consists of 3 exons, and is similar to murine ALR genomic DNA structure. The human ALR genomic DNA is 1813 nt long and codes a protein of 125 amino acid residues.
Conclusion: Human genomic DNA of ALR consists of 3 exons and 2 introns.
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