On the basis of studies with animal models, the gene for the low-affinity receptor for immunoglobulin E (IgE) (FCER2, CD23) has been implicated as a candidate for IgE-mediated allergic diseases and bronchial hyperreactivity, or related traits. Given evidence for genetic complexity in atopic disorders, we sought to study two European subpopulations, Finnish and Catalonian. We studied three phenotypic markers: (1) total serum IgE level; (2) asthma; and (3) specific IgE level for a mixture of the most common aeroallergens in Finland. Altogether, eight polymorphic markers spanning a region of 10 cM around the FCER2 gene on chromosome 19p13 were analyzed in 124 families. The physical order of the markers and the location of the FCER2 gene were confirmed by using radiation hybrids. The allele and haplotype association study showed a suggestive haplotype association (significance of p
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[Multi-omics genetic association analysis identifies susceptibility risk gene of acute viral respiratory infections in multi-ancestry populations and screening of potential traditional Chinese medicines].
Zhongguo Zhong Yao Za Zhi
October 2024
Nanjing University of Chinese Medicine Nanjing 210023, China Jiangsu Society for Ageing Development Nanjing 210008, China.
Article Synopsis
- The study focuses on identifying genetic risk factors for acute viral respiratory infections (ARI) and integrating traditional Chinese medicine (TCM) in their prevention through multi-omics analysis across various global populations.
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November 2024
Department of Neurology, University Hospital Heidelberg, Heidelberg University, Heidelberg, Germany.
Background: Epstein-Barr virus (EBV)+ and EBV- primary CNS lymphomas (PCNSL) carry distinct mutational landscapes, but their transcriptional and epigenetic profiles have not been integrated and compared. This precludes further insights into pathobiology and molecular differences, relevant for classification and targeted therapy.
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Rare/Common Variants Are Associated with Inhaled Corticosteroid Response among Children with Asthma.
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Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.
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Sci Transl Med
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Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
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