The aim of our study was to evaluate hemorheological parameters in two groups of patients both suffering from essential hypertension compared with an homologous group of subjects not suffering from hypertension; the 1st group was composed of 16 patients (8 females and 8 males, mean age 65.6 +/- 16.5) suffering from essential hypertension; the 2nd one of 26 patients (8 females and 18 males, mean age 74.3 +/- 11.7) suffering from essential hypertension and cerebral or cardiac ischemia in a chronic phase. The group of controls was composed of 20 subjects (mean age 50.5 +/- 11.5). In all these subjects we evaluated: blood viscosity, hematocrit, plasmatic fibrinogen, red cell morphology according to Zipursky-Forconi method and blood pressure. Our results show that blood viscosity and fibrinogen were statistically increased relative to controls. Comparison between these groups leads us to observe that blood viscosity and fibrinogen are slightly higher in the first group in a statistically significant way (7.5 +/- 1.1 cPs 10 s(-1) 1st group, 7.9 +/- 1.05 cPs 10 s(-1) 2nd group; 362.2 +/- 167.3 mg% 1st group, 384.6 +/- 106.9 mg% 2nd group). Blood pressure was higher in the second group. The study of red cell morphology in all the patients showed a prevalence in the percentage of discocytes, cells which have less deformability compared to bowls. The study demonstrated EMI (Erythrocyte Morphology Index) decreased in a statistically significant way compared to controls (0.70 +/- 0.03 1st group; 0.65 +/- 0.02 2nd group; 1.2 +/- 0.09 control group). In subjects suffering from essential hypertension with end-organ damage EMI further decreases. So we observed that hypertension is also delineated by the increase in the discocytes percentage which results in reduction of the red cell deformability. In conclusion, when hypertension causes end-organ damage, the hemorheological alterations, which implicate a worsening in microcirculation, are more evident.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Dense stroma activates the TGF-β1/FBW7 axis to induce metabolic subtype switching in pancreatic cancer.
Int J Surg
January 2025
Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases. Although several chemotherapy regimens have been developed over the past decades, few targeted therapies have shown a significant improvement in overall survival, partly due to the identification of PDAC as a single disease.
Methods: Combining metabolomic analysis and immunohistochemistry staining with Oil Red O staining, analysis for the oxygen consumption rate and extracellular acidification rate, we stratified pancreatic cancer cells into two subtypes.
Association Between Red-Cell Transfusion in Childbirth and Long-Term Risk of Lymphoma and Autoimmune Disease: A Swedish Nationwide Cohort Study.
Am J Hematol
January 2025
Department of Medicine, Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a well-known red blood cell enzymopathy and a cause of intravascular hemolysis. This case report presents a child with underlying G6PD deficiency who experienced an acute episode of extensive intravascular hemolysis induced by a scrub typhus infection. The key takeaway from this report is that scrub typhus infection can trigger extensive hemolysis in patients with even "mild" G6PD deficiency, and normal G6PD levels found during the acute phase of hemolysis do not rule out the possibility of underlying G6PD deficiency.
View Article and Find Full Text PDFUnlabelled: Once considered rare in eukaryotes, polycistronic mRNA expression has been identified in kinetoplastids and, more recently, green algae, red algae, and certain fungi. This study provides comprehensive evidence supporting the existence of polycistronic mRNA expression in the apicomplexan parasite . Leveraging long-read RNA-seq data from different parasite strains and using multiple long-read technologies, we demonstrate the existence of defined polycistronic transcripts containing 2-4 protein encoding genes, several validated with RT-PCR.
View Article and Find Full Text PDFBacterial strains that are genetically engineered to constitutively produce fluorescent proteins have aided our study of bacterial physiology, biofilm formation, and interspecies interactions. Here, we report on the construction and utilization of new strains that produce the blue fluorescent protein mTagBFP2, the green fluorescent protein sfGFP, and the red fluorescent protein mScarlet-I3 in species , and . Gene fragments, developed to contain the constitutive promoter P , the fluorescent gene of interest as well as , providing resistance to the antibiotic spectinomycin, were inserted into selected open reading frames on the chromosome that were both transcriptionally silent and whose loss caused no measurable changes in fitness.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!