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Beneath the Surface: Diagnosing Gastric Linitis Plastica.
J Community Hosp Intern Med Perspect
November 2024
MedStar Health Internal Medicine Residency Program, Baltimore, MD, USA.
Gastric Linitis plastica is characterized by extensive infiltration of gastric wall by poorly differentiated tumor cells, creating a "leather-bottle stomach" appearance. We describe a case involving a 71-year-old male presenting with globus sensation, early satiety and weight loss. Recent EGD had revealed chronic gastritis with polypoid mucosa at the GE junction, and subsequent FDG-PET indicated asymmetric FDG localization.
View Article and Find Full Text PDFMicroangiopathic Hemolytic Anemia as the Initial Presentation of Metastatic Signet-Ring Cell Carcinoma of the Colon: A Case Report.
Cureus
December 2024
Internal Medicine, Hurley Medical Center, Flint, USA.
Microangiopathic hemolytic anemia (MAHA) is a condition characterized by intravascular fragmentation of red blood cells, leading to the characteristic finding of schistocytes on a peripheral blood smear. The differential diagnoses of MAHA include thrombotic thrombocytopenic purpura (TTP), hemolytic-uremic syndrome (HUS), disseminated intravascular coagulation (DIC), idiopathic thrombocytopenic purpura (ITP), infections, malignancies, and solid organ transplantation. The commonly associated malignancies with MAHA are gastric, breast, prostate, lung, and lymphoma.
View Article and Find Full Text PDFConnecting the dots: Low-grade appendiceal mucinous neoplasms and serrated polyps in the appendix.
Am J Clin Pathol
January 2025
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, United States.
Objective: This study aimed to examine the relationship between low-grade appendiceal mucinous neoplasms (LAMNs) and serrated polyps (SPs) of the appendix, both characterized by KRAS mutations and overlapping morphologic features.
Methods: We analyzed 27 cases of LAMN and 24 cases of SP from archival records, reviewed pathology, and performed molecular analysis on select cases. Four cases initially diagnosed as LAMN were excluded for not meeting diagnostic criteria, and 1 SP case was reclassified as LAMN.
Gastric carcinoma leading to metastatic spinal cord compression.
J Pak Med Assoc
January 2025
Department of Oncology, Ziauddin University, Karachi, Pakistan.
Gastric cancer is described as a malignancy occurring in the region between the gastroesophageal junction and the pylorus. According to the histology, majority of gastric cancers are classified as adenocarcinomas. The prevalence of bone metastasis in the general population is 2-3%.
View Article and Find Full Text PDFPrimary signet ring cell carcinoma of the lung in patient with superior vena cava syndrome and lymphangitic carcinomatosis: a case report.
Intern Emerg Med
January 2025
Department of Clinical and Experimental Medicine, Internal Medicine Unit, University of Catania, University Hospital G.Rodolico, Catania, Italy.
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