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Key Biophysical and Physiological Properties Impacting the Oxygenation Status of Breast Cancers During Thermo-radiotherapy.
Adv Exp Med Biol
October 2024
Department of Radiation Oncology, Medical Center - University of Freiburg, University of Freiburg, Freiburg, Germany.
Article Synopsis
- Mild hyperthermia (39-43 °C) is used locoregionally for 30-60 minutes to enhance oxygenation in recurrent breast cancers, which can improve the effectiveness of various treatments like radiotherapy, chemotherapy, and immunotherapy.!* -
- Data from clinical trials and experiments show that breast cancer tissue generally has higher water content and density compared to normal breast tissue, and these values increase during mild hyperthermia.!* -
- Key factors affecting oxygenation in both healthy and cancerous breast tissue include blood flow, interstitial fluid dynamics, and tissue permeability, with most parameters improving under mild hyperthermia treatment.!*
Cu-doped polypyrrole hydrogel with tumor catalyst activity for NIR-II thermo-radiotherapy.
Front Bioeng Biotechnol
July 2023
The Research and Application Center of Precision Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Radiotherapy (RT) is one of the key methods for treating breast cancer. However, the effect of single RT is often poor because of insufficient deposition of X-rays in tumor sites and radiation resistance induced by the abnormal tumor microenvironment (overexpression of glutathione (GSH)). The development of multifunctional RT sensitizers and synergetic therapeutic strategies is, therefore, a promising area for enhancing the anticancer effect of RT.
View Article and Find Full Text PDFEvaluation of the Heat Shock Protein 90 Inhibitor Ganetespib as a Sensitizer to Hyperthermia-Based Cancer Treatments.
Cancers (Basel)
October 2022
Department of Medical Biology, Amsterdam University Medical Centers, Cancer Center Amsterdam, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Hyperthermia is being used as a radio- and chemotherapy sensitizer for a growing range of tumor subtypes in the clinic. Its potential is limited, however, by the ability of cancer cells to activate a protective mechanism known as the heat stress response (HSR). The HSR is marked by the rapid overexpression of molecular chaperones, and recent advances in drug development make their inhibition an attractive option to improve the efficacy of hyperthermia-based therapies.
View Article and Find Full Text PDFLipid-coated bismuth nanoflower as the thermos-radio sensiti for therapy of lung metastatic breast cancer: Preparation, optimisation, and characterisation.
IET Nanobiotechnol
December 2022
Department of Pharmacy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
Lung metastatic breast cancer (LMBC) leads to a large number of deaths in women with breast cancer, and radiotherapy has been considered the common assay for tumour therapy except for surgery. However, radiotherapy still faces problems of low efficiency due to resistance and easily induced side effects. Here, the authors designed lipid-decorated bismuth-based nanoflowers (DP-BNFs) as both a radiosensitiser and a photothermal therapy agent for LMBC treatment.
View Article and Find Full Text PDFIron oxide/gold nanoparticles-decorated reduced graphene oxide nanohybrid as the thermo-radiotherapy agent.
IET Nanobiotechnol
July 2020
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
The main focus of the current study is the fabrication of a multifunctional nanohybrid based on graphene oxide (GO)/iron oxide/gold nanoparticles (NPs) as the combinatorial cancer treatment agent. Gold and iron oxide NPs formed on the GONPs via the in situ synthesis approach. The characterisations showed that gold and iron oxide NPs formed onto the GO.
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