We investigated whether chronic stress, applied from prepuberty to early puberty, interferes with the spermatogenic and androgenic testicular functions. Male pubertal rats (40 days old) were immobilized 6 h per day for 15 days. Plasma concentrations of corticosterone, prolactin and testosterone were significantly augmented following immobilization, whereas plasma luteinizing hormone decreased and follicle-stimulating hormone was not altered. Acute immobilization (5 min) increased prolactin and testosterone levels in control rats but caused a significantly higher increase in these hormones when superimposed on chronic stress. A lower extent of testicular maturation was observed in pubertal rats immobilized from prepuberty.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Pubertal stress accelerates copulation in adult male rats: Mitigating effects of a high-calorie diet in adulthood.
Physiol Behav
December 2024
Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Avenida Luis Castelazo s/n Col. Industrial Ánimas, Xalapa, Veracruz C. P. 91190. Mexico.
The pubertal phase involves significant brain reorganization, where external stressors and diet can profoundly influence long-term behavioral outcomes. In this study, we investigated the interaction between acute pubertal stress (via immune challenge) and a hypercaloric diet in adulthood on the copulatory sexual behavior of male Wistar rats. At postnatal day (PND) 35, pubertal males received a single injection of lipopolysaccharide (LPS, 1.
View Article and Find Full Text PDFThe Regulatory Effect of Insulin-Like Growth Factor-2 on Hypothalamic Gonadotropin-Releasing Hormone Neurons during the Pubertal Period.
J Integr Neurosci
November 2024
Department of Traditional Chinese Medicine, Children's Hospital of Fudan University, 201102 Shanghai, China.
Background: The insulin-like growth factor (IGF) system plays a vital role in regulating gonadotropin-releasing hormone (GnRH), whether the IGF2 can act on the GnRH neurons during the pubertal period is unclear.
Methods: Central precocious puberty (CPP) rats were induced by danazol, and when the rats met the first diestrus, they were euthanized and tissues were collected. GT1-7 cells were cultured and treated with 0, 1, 10 ng/mL IGF2 for 4 hours and the changes in GnRH were measured.
The antidepressant-like effects of kisspeptin-10 are reversed by kisspeptin antagonist peptide 234 in male rats.
Cell Mol Biol (Noisy-le-grand)
November 2024
Department of Physiology, Medical School, Istanbul Okan University, Istanbul, Turkey.
Kisspeptins are reported to be the most potent activators of the hypothalamus-pituitary-gonadal (HPG) axis known to date. Kisspeptin potently elicits gonadotropin-releasing hormone (GnRH) release and luteinizing hormone (LH) secretion, even in the pre-pubertal period. Beyond the hypothalamus, kisspeptin is also expressed in limbic and paralimbic brain regions, which are areas of the neurobiological network primarily implicated in emotional behaviors alongside sexual functions.
View Article and Find Full Text PDFImproving the Dehydroepiandrosterone Induced PCOS Rat Model: Interplay of Age, High Fat Diet, and Treatment Regimen on Reproductive and Metabolic Phenotypes.
Reprod Sci
January 2025
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
Polycystic ovary syndrome (PCOS) is a ubiquitous reproductive condition with triggering hallmarks such as glucose intolerance, hyperandrogenism, and dyslipidemia. Despite the existence of various PCOS animal models, an ideal model which could encompass all PCOS-specific phenotype is of dire need. Dehydroepiandrosterone (DHEA) induced PCOS rats are frequently employed; though, determining the superior model among pubertal and prepubertal rats, incorporation of high fat diet (HFD), and their sustainability remains uncertain.
View Article and Find Full Text PDFpiRNA array analysis provide insight into the mechanism of DEHP-induced testicular toxicology in pubertal male rats.
Ecotoxicol Environ Saf
November 2024
Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, China; School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China. Electronic address:
Di-(2-ethylhexyl) phthalate (DEHP), a widely used plasticizer, could cause male reproductive toxicity by disrupting spermatogenesis. Piwi-interacting RNAs (piRNAs) are a small non-coding RNAs specifically highly expressed in the germline and interact with PIWI proteins to regulate spermatogenesis. Accumulating studies have confirmed that environmental poisons could induce male reproductive injury via altering piRNA expression.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!