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Automated Screening of Precancerous Cervical Cells Through Contrastive Self-Supervised Learning.
Life (Basel)
November 2024
Clinical Omics Institute, Kyungpook National University, Daegu 41405, Republic of Korea.
Cervical cancer is a significant health challenge, yet it can be effectively prevented through early detection. Cytology-based screening is critical for identifying cancerous and precancerous lesions; however, the process is labor-intensive and reliant on trained experts to scan through hundreds of thousands of mostly normal cells. To address these challenges, we propose a novel distribution-augmented approach using contrastive self-supervised learning for detecting abnormal squamous cervical cells from cytological images.
View Article and Find Full Text PDFPredictive Factors of Athyroglobulinemia After Total Thyroidectomy for Papillary Thyroid Cancer.
Cancers (Basel)
December 2024
Endocrine Surgery Unit, General Surgery Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain.
: Thyroglobulin (Tg) is the specific tumor marker for epithelial thyroid cancer. It holds significant value in the postoperative period, and somehow, the goal of surgery in papillary thyroid cancer (PTC) undergoing total thyroidectomy is to achieve undetectable levels of postoperative thyroglobulin (uTg). : This is a retrospective single-center study in which first basal Tg values were evaluated post-surgery in PTC patients undergoing total thyroidectomy.
View Article and Find Full Text PDFCervical screening with self-sampling for postmenopausal women with molecular triage using extended genotyping and methylation.
Eur J Obstet Gynecol Reprod Biol
January 2025
Department of Women's Health, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Objective: With the transition from cytology to human papilloma virus (HPV) testing in cervical cancer screening, it is possible to use self-sampling instead of professionally collected samples. Most studies have included women between 20 and 60 years age. Here we aimed to study postmenopausal women and investigate whether vaginal self-sampling is equally effective as professional sampling for detection of HSIL and the possibility to use a method for molecular triage directly on the screening sample.
View Article and Find Full Text PDFIdentification of DNA methylation signatures in follicular-patterned thyroid tumors.
Pathol Res Pract
December 2024
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand; Precision Pathology of Neoplasia Research Group, Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address:
Background And Aims: Follicular-patterned thyroid tumors (FPTTs) are frequently encountered in thyroid pathology, encompassing follicular adenoma (FA), follicular thyroid carcinoma (FTC), noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), and follicular variant of papillary thyroid carcinoma (fvPTC). Recently, a distinct entity termed differentiated high-grade thyroid carcinoma has been described by the 5th edition of the WHO classification of the thyroid tumors, categorized as either high-grade fvPTC, high-grade FTC or high-grade oncocytic carcinoma of the thyroid (OCA). Accurate differentiation among these lesions, particular between the benign (FA), borderline (NIFTP) and malignant neoplasms (FTC and fvPTC), remains a challenge in both histopathological and cytological diagnoses.
View Article and Find Full Text PDFTreatment Outcomes of Canine Orbital Meningiomas in Seven Cases.
J Am Anim Hosp Assoc
January 2025
Laboratory of Veterinary Clinical Oncology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan (T.M.).
Although intracranial and spinal cord meningioma prognoses have been reported, few studies have evaluated the outcomes and prognoses of orbital and optic nerve meningiomas in dogs. We aimed to evaluate the outcomes of canine orbital meningiomas. The seven dogs included were cytologically or histopathologically diagnosed with meningiomas.
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