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Anemia in diabetes mellitus: Pathogenetic aspects and the value of early erythropoietin therapy.
Metabol Open
March 2025
First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Anemia is a frequent, yet increasingly recognized, comorbidity in diabetes mellitus (DM), with prevalence often driven by multifactorial mechanisms. Hematinic deficiencies, common in this population, may arise from associated comorbidities or medications, such as metformin, as well as other drugs commonly employed for DM-related conditions. Among contributing factors, diabetic kidney disease (DKD) plays a pivotal role, with anemia developing more frequently and being more pronounced in earlier stages, than in CKD of other causes.
View Article and Find Full Text PDFDealing With Rape Cases in Ghana: The Law, the Victim and the Offender.
Sex Offending
December 2023
Narcotics Control Commission, Accra, Ghana.
Rape is a criminal offence in all countries of the world. However, what constitutes rape in the legal sense differs from country to country, with many common law countries sharing some similarities in their definition of rape. This paper conducts a critical review of the crime of rape in Ghana by discussing what constitutes rape under Ghanaian law, its key elements which a prosecution has to prove to succeed on a charge of rape, and the challenges of adjudicating rape cases in Ghana, paying particular attention to the victim.
View Article and Find Full Text PDFA novel classification method for balance differences in elite versus expert athletes based on composite multiscale complexity index and ranking forests.
PLoS One
January 2025
School of Exercise and Health, Shenyang Sport University, Shenyang, China.
Balance is crucial for various athletic tasks, and accurately assessing balance ability among elite athletes using simple and accessible measurement methods is a significant challenge in sports science. A common approach to balance assessment involves recording center of pressure (CoP) displacements using force platforms, with various indicators proposed to distinguish subtle balance differences. However, these indicators have not reached a consensus, and it remains unclear whether these analyses alone can fully explain the complex interactions of postural control.
View Article and Find Full Text PDFGuards and decoys: RIPoptosome and inflammasome pathway regulators of bacterial effector-triggered immunity.
PLoS Pathog
January 2025
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America.
Virulent microbes produce proteins that interact with host cell targets to promote pathogenesis. For example, virulent bacterial pathogens have proteins called effectors that are typically enzymes and are secreted into host cells. To detect and respond to the activities of effectors, diverse phyla of host organisms evolved effector-triggered immunity (ETI).
View Article and Find Full Text PDFA yeast-based reverse genetics system to generate HCoV-OC43 reporter viruses encoding an eighth subgenomic RNA.
J Virol
January 2025
Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.
Unlabelled: Coronaviruses have large, positive-sense single-stranded RNA genomes that challenge conventional strategies for mutagenesis. Yeast genetics has been used to manipulate large viral genomes, including those of herpesviruses and coronaviruses. This method, known as transformation-associated recombination (TAR), involves assembling complete viral genomes from dsDNA copies of viral genome fragments via homologous recombination in .
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