In mice, there is evidence suggesting that the development of head and trunk structures is organized by distinctly separated cell populations. The head organizer is located in the anterior visceral endoderm (AVE) and the trunk organizer in the node and anterior primitive streak. In amphibians, Spemann's organizer, which is homologous to the node, partially overlaps with anterior endoderm cells expressing homologues of the AVE markers cerberus, Hex and Hesx1. For mice, this raises the question of whether the AVE and node are independent of each other, as suggested by their anatomical separation, or functionally interdependent as is the case in amphibians. Chordin and Noggin are secreted bone morphogenetic protein (BMP) antagonists expressed in the mouse node, but not in the AVE. Here we show that mice double-homozygous mutants that are for chordin and noggin display severe defects in the development of the prosencephalon. The results show that BMP antagonists in the node and its derivatives are required for head development.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/35001072 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Molecular analysis of a self-organizing signaling pathway for axial patterning from egg to tailbud.
Proc Natl Acad Sci U S A
July 2024
Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662.
embryos provide a favorable material to dissect the sequential steps that lead to dorsal-ventral (D-V) and anterior-posterior (A-P) cell differentiation. Here, we analyze the signaling pathways involved in this process using loss-of-function and gain-of-function approaches. The initial step was provided by Hwa, a transmembrane protein that robustly activates early β-catenin signaling when microinjected into the ventral side of the embryo leading to complete twinned axes.
View Article and Find Full Text PDFThe Molecular Mechanism of Body Axis Induction in Lampreys May Differ from That in Amphibians.
Int J Mol Sci
February 2024
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia.
Lamprey homologues of the classic embryonic inducer Noggin are similar in expression pattern and functional properties to Noggin homologues of jawed vertebrates. All genes of vertebrates apparently originated from a single ancestral gene as a result of genome duplications. , and of lampreys, like and of gnathostomes, demonstrate the ability to induce complete secondary axes with forebrain and eye structures when overexpressed in embryos.
View Article and Find Full Text PDFMethotrexate inhibits BMP4 and abrogates the hypertrophic chondrocyte phenotype of synovial fibroblasts in juvenile idiopathic arthritis.
Pediatr Rheumatol Online J
January 2024
Nemours Children's Health, Delaware, 1600 Rockland Rd, Wilmington, DE, 19803, USA.
Background: Juvenile Idiopathic Arthritis (JIA) induces growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis. FLS overexpress bone morphogenetic protein 4 (BMP4) and have a chondrocyte-like phenotype.
View Article and Find Full Text PDFMolecular understanding of the vertebrate Organizer, a tissue center critical for inductive signaling during gastrulation, has so far been limited to transcripts and some proteins due to limitations in detection and sensitivity. The Spemann-Mangold Organizer (SMO) in the South African Clawed Frog ( ), a popular model of development, has long been discovered to induce the patterning of the central nervous system. Molecular screens on the tissue have identified several genes, such as goosecoid, chordin, and noggin, with independent ability to establish a body axis.
View Article and Find Full Text PDFBMP signaling is required to form the anterior neural plate border in ascidian embryos.
Dev Genes Evol
June 2023
Department of Zoology, Graduate School of Science, Kyoto University, Sakyo, Kyoto, 606-8502, Japan.
Article Synopsis
- Cranial neurogenic placodes were long thought to be unique to vertebrates, but recent findings suggest that ascidian embryos have similar structures, indicating a common ancestor.
- BMP signaling plays a crucial role in defining the anterior neural plate border (ANB) region in ascidians, involving a BMP family member called Admp and its antagonists Noggin and Chordin.
- Disruption of BMP signaling affects gene expression related to the development of adhesive organs in ascidians, supporting the idea that ANB cells are evolutionarily linked to vertebrate neurogenic placodes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!