RFLP analysis of amplified genes for cytochrome b and NADP dehydrogenase 5/6 of sable mtDNA was carried out. Polymorphism was recorded in the first and the second fragment using six and four enzymes, respectively. This allowed us to identify seven mtDNA haplotypes forming two clusters, A1-A3 and B1-C2. The divergence between the clusters was 0.0112-0.0164. An association between mutations of genes for cytochrome b and NADP dehydrogenase 5/6 was established. This association can be explained by high mutability of the fragments containing the associated mutations.
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