[The effect of divalent cations on pepsinogen extrusion by permeable isolated gastric glands].

The model of permeable gastric glands obtained by its incubation with digiton (15 mg/ml) had investigated. It was shown, that stimulated influence of Ca2+ ions on pepsinogen extrusion completely or partly reproduced by cations of transient metals. Stimulated effects of cations of metals (5 x 10(-4) M) decrease in such order: Ca2+ > Cd2+ > Mn2+ > Co2+ > La3+. Nevertheless, Co2+ and La3+ in the same concentrations inhibit Ca2+ stimulated extrusion of pepsinogen by permeable isolated glands. Stimulated effect of Cd2+ and La3+ on pepsinogen extrusion in native glands was not reproducible. Besides these cations inhibit carbacholine-stimulated extrusion in native glands. It's concluded, that influence of metal cations on secretory function of gastric glands to a great extent is determined by their property to penetrate into secretory cells and cooperate with their plasma membranes.