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Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice.
Genesis
February 2000
Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Human COL2A1-directed SV40 T antigen expression in transgenic and chimeric mice results in abnormal skeletal development.
J Cell Biol
January 1995
Department of Biochemistry, Hong Kong University.
The ability of SV40 T antigen to cause abnormalities in cartilage development in transgenic mice and chimeras has been tested. The cis-regulatory elements of the COL2A1 gene were used to target expression of SV40 T antigen to differentiating chondrocytes in transgenic mice and chimeras derived from embryonal stem (ES) cells bearing the same transgene. The major phenotypic consequences of transgenic (pAL21) expression are malformed skeleton, disproportionate dwarfism, and perinatal/neonatal death.
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