Initiating and Maintaining Patients on Warfarin Anticoagulation: The Importance of Monitoring.

J Cardiovasc Pharmacol Ther

Cardiology Section, VA Medical Center, West Haven, Connecticut, USA

Published: January 1999

BACKGROUND: The VA Stroke Prevention in Nonrheumatic Atrial Fibrillation study was a prospective, randomized, double-blind study comparing low-dose warfarin with placebo in patients with nonrheumatic atrial fibrillation. The trial showed a 79% reduction in stroke rate in warfarin randomized patients without an increase in bleeding complications. We examined the need for frequent prothrombin time monitoring (international normalized ratios [INR] were not measured directly) in patients receiving warfarin.

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http://dx.doi.org/10.1177/107424849900400102DOI Listing

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