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Jessner Lymphocytic Infiltrate in Anti-HMGCR Myopathy.
JAMA Dermatol
December 2024
Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Anti-HMGCR myopathy: Diversity of clinical presentations in a national cohort in New Zealand.
Semin Arthritis Rheum
October 2024
Department of Immunology, Canterbury Health Laboratories, Christchurch, New Zealand.
Aims: We describe the varied clinical presentations, barriers in diagnosis and outcomes of anti-HMGCR myopathy in a large national cohort.
Methods: Adults found positive for serum anti-HMGCR autoantibodies via line blot or enzyme-immunoassay followed by immunoprecipitation were included in the study.
Results: Of 75 patients identified, the records of 72 (96 %) described weakness as the presenting symptom.
Lupus Erythematosus Tumidus Misdiagnosed as Erythema Nodosum from Coccidioidomycosis.
Case Rep Dermatol
May 2024
Department of Public Health and Preventive Medicine, St. George's University School of Medicine, St. George, Grenada.
Article Synopsis
- Lupus erythematosus tumidus (LET) is a rare skin condition that can be difficult to diagnose due to its similarities with other skin disorders.
- A case involving a 52-year-old Hispanic female revealed that she was initially misdiagnosed with erythema nodosum and treated ineffectively before tests confirmed LET.
- The patient responded well to treatment with hydroxychloroquine, highlighting the importance of confirmatory testing before starting treatment for skin conditions like LET.
Lupus Erythematosus Tumidus as a Distinct Uncommon Subtype of Cutaneous Lupus Erythematosus: A Case Report and Review.
Cureus
April 2024
Dermatopathology, Riverchase Dermatology, Fort Myers, USA.
Lupus erythematosus tumidus (LET) is an uncommon but distinct photosensitive subtype of cutaneous lupus erythematosus (CLE). It differs from discoid and subacute cutaneous lupus erythematosus (SCLE) clinically and pathologically. LET is marked by extreme photosensitivity and carries a much lower risk of progression to systemic disease.
View Article and Find Full Text PDFAtypical skin conditions of the neck and back as a dermal manifestation of anti-HMGCR antibody-positive myopathy.
BMC Immunol
May 2024
Department of Neurology, NHO Kure Medical Center, Chugoku Cancer Center, Kure, Japan.
Article Synopsis
- Immune-mediated necrotizing myopathy (IMNM) is an inflammatory muscle disease that typically doesn't present with skin rashes, but patients with the specific HMGCR antibody may exhibit atypical skin conditions.
- A study of 100 IIM patients revealed that 34% had skin conditions, with 42% of those with HMGCR-IMNM showing atypical lesions, which were distinct from typical IIM-related rashes.
- Skin biopsies from HMGCR-IMNM patients revealed similar microscopic features, specifically Bcl-2-positive lymphocyte infiltrations, suggesting that these atypical skin manifestations could be a clue for diagnosing HMGCR-IMNM.
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