Two studies were conducted using a single subject research design in different business environments to evaluate the efficacy of the Sonic Pathfinder for increasing efficiency in travel with an experienced and accomplished blind traveller. The Sonic Pathfinder is one of eight or nine commercially available electronic travel aids (ETAs) designed for use by blind or visually impaired persons. The use of ETAs are thought to result in more rapid travel and a greater ability to detect and avoid obstacles in one's path. Elapsed time for travel and the number of unintentional contacts made while travelling were used as the dependent variables in both studies. No marked effect was observed for either variable in either study. An additional traveller who was slower and more tenuous in his movements was recruited to participate in the second study to investigate the possibility that a floor effect may have masked the results of the use of the ETA with the first subject. However, no marked effects were observed with this subject either. Yet, both subjects stated that the use of the aid increased their distance for environmental preview over and above that provided by the long cane alone, while providing them with the opportunity to judge the distance of objects approached beyond cane length. Discussion centers on the need to identify other means to evaluate the utility of this aid in light of the positive statements made by the participants of these studies.
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Pharmaceutics
August 2022
Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Poly(lactic-co-glycolic acid) (PLGA) nanoparticle-based drug delivery systems are known to offer a plethora of potential therapeutic benefits. However, challenges related to large-scale manufacturing, such as the difficulty of reproducing complex formulations and high manufacturing costs, hinder their clinical and commercial development. In this context, a reliable manufacturing technique suitable for the scale-up production of nanoformulations without altering efficacy and safety profiles is highly needed.
View Article and Find Full Text PDFCell Mol Life Sci
November 2000
Department of Pathology, School of Medicine, University of Southern California, Los Angeles 90033, USA.
Vertebrate epithelial appendages are elaborate topological transformations of flat epithelia into complex organs that either protrude out of external (integument) and internal (oral cavity, gut) epithelia, or invaginate into the surrounding mesenchyme. Although they have specific structures and diverse functions, most epithelial appendages share similar developmental stages, including induction, morphogenesis, differentiation and cycling. The roles of the SHH pathway are analyzed in exemplary organs including feather, hair, tooth, tongue papilla, lung and foregut.
View Article and Find Full Text PDFJ Rehabil Res Dev
October 1999
School of Health Sciences, Massey University Palmerston North, New Zealand.
Two studies were conducted using a single subject research design in different business environments to evaluate the efficacy of the Sonic Pathfinder for increasing efficiency in travel with an experienced and accomplished blind traveller. The Sonic Pathfinder is one of eight or nine commercially available electronic travel aids (ETAs) designed for use by blind or visually impaired persons. The use of ETAs are thought to result in more rapid travel and a greater ability to detect and avoid obstacles in one's path.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!