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A Systematic Review on the Effectiveness and Safety of Combining Biostimulators with Botulinum Toxin, Dermal Fillers, and Energy-Based Devices.
Aesthetic Plast Surg
December 2024
Research and Innovation Hub, Innovation Aesthetics, London, WC2H 9JQ, UK.
Introduction: Aesthetic medicine has evolved towards minimally invasive procedures, with biostimulators like Poly-L-Lactic Acid (PLLA), Calcium Hydroxylapatite (CaHA), and Polycaprolactone (PCL) gaining attention for their role in collagen induction, improving skin texture, elasticity, and volume. Combining these agents with other treatments-such as botulinum toxin, dermal fillers, and energy-based devices (e.g.
View Article and Find Full Text PDFThe impact of anesthesia instruments and drugs on the occurrence of vocal cord injury, systematic review and meta-analysis.
Eur Arch Otorhinolaryngol
November 2024
Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Objective: This study extensively examined common complications related to anesthesia drugs and equipment on vocal cords. It also delved into factors such as smoking, anesthesia duration and anesthesia induction methods. Overall, the research aimed to pinpoint influential factors for creating a general anesthesia protocol with minimal post-operative complications.
View Article and Find Full Text PDFGlucocorticoids versus glucocorticoids plus cyclophosphamide in eosinophilic granulomatosis with polyangiitis with poor-prognosis factors.
J Autoimmun
December 2024
Department of Internal Medicine, Cochin Hospital, National Referral Center for Rare Systemic Autoimmune and Autoinflammatory Diseases of Ile de France, East and West, Assistance Publique - Hôpitaux de Paris, F-75014 Paris, France; Paris Cité University, F-75006, Paris, France. Electronic address:
Article Synopsis
- The study aimed to assess the effectiveness of combining glucocorticoids (GCs) with cyclophosphamide (CYC) for treating patients with poor-prognosis eosinophilic granulomatosis with polyangiitis (EGPA) compared to using GCs alone.
- Data from a European multicenter database were analyzed, involving 209 patients and focusing on relapse rates and other related outcomes over 12 to 24 months.
- Results indicated that adding CYC significantly reduced the risk of relapse and related complications compared to GCs alone, suggesting a beneficial role for CYC in the treatment of poor-prognosis EGPA.
Establishment of CD1b-restricted immunity to lipid antigens in the pulmonary response to infection.
Infect Immun
December 2024
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
CD1 is an antigen-presenting glycoprotein homologous to MHC I; however, CD1 proteins present lipid rather than peptide antigens. CD1 proteins are well established to present lipid antigens of (Mtb) to T cells, but understanding the role of CD1-restricted immunity in response to Mtb infection has been limited by the availability of animal models naturally expressing the CD1 proteins implicated in human response: CD1a, CD1b, and CD1c. Guinea pigs, in contrast to other rodent models, express four CD1b orthologs, and here we utilize the guinea pig to establish the kinetics of gene and protein expression of CD1b orthologs, as well as the Mtb lipid-antigen and CD1b-restricted immune response at the tissue level over the course of Mtb infection.
View Article and Find Full Text PDFIs playing a part in liver carcinogenesis?
J Helminthol
October 2024
Institute for Globally Distributed Open Research and Education (IGDORE), India.
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- * While there's evidence of Sm's role in promoting chronic inflammation and fibrosis, along with hepato-toxic agents like soluble egg antigens (SEAs), definitive proof of its independent cancer-inducing ability in humans is lacking.
- * The research indicates that Sm infection may enhance the risk and aggressiveness of HCC in the presence of other factors, but more studies are needed to establish whether Sm can cause cancer on its own.
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