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Local anaesthesia systemic toxicity following erector spinae plane block: Does dose matter?
Am J Emerg Med
January 2025
Department of Anesthesiology and Critical Care, All India Institute of Medical Sciences, Bhubaneswar, India.
Quercetin attenuated ropivacaine-induced neurotoxicity in SH-SY5Y cells through upregulating Pim1 and enhancing autophagy.
Heliyon
July 2024
Department of Anesthesia, People's Liberation Army the General Hospital of Western Theater Command, Chengdu, Sichuan, 610083, China.
Background: Ropivacaine (Rop) is a local anesthetic that is widely used but is also potentially harmful. Quercetin (Quer) is a flavonoid component found in many plants and traditional Chinese medicines. It possesses anti-oxidant, anti-inflammatory, antitumor, and neuroprotective properties as a pharmaceutical.
View Article and Find Full Text PDFVaginal infiltration for relief of neuropathic pain after sacrospinous hysteropexy: First successful mid-term report.
Medwave
January 2025
Unidad de Ginecología, Hospital El Carmen Dr. Luis Valentín Ferrada, Santiago, Camino Rinconada 1202 Maipú, 9274443, Chile.
Female genital prolapse, especially apical prolapse, significantly affects women's health and quality of life. Sacrospinous hysteropexy is a widely used surgical procedure to address this condition, presenting few postoperative complications. However, one of the reported complications is neuropathic pain resulting from damage to the branches of the pudendal nerve.
View Article and Find Full Text PDFRestorative Neurostimulation Therapy Compared to Optimal Medical Management: A Randomized Evaluation (RESTORE) for the Treatment of Chronic Mechanical Low Back Pain due to Multifidus Dysfunction.
Pain Ther
January 2025
Robert Wood Johnson University Hospital/Rutgers Medical School, New Brunswick, NJ, USA.
Introduction: Many interventional strategies are commonly used to treat chronic low back pain (CLBP), though few are specifically intended to target the distinct underlying pathomechanisms causing low back pain. Restorative neurostimulation has been suggested as a specific treatment for mechanical CLBP resulting from multifidus dysfunction. In this randomized controlled trial, we report outcomes from a cohort of patients with CLBP associated with multifidus dysfunction treated with restorative neurostimulation compared to those randomized to a control group receiving optimal medical management (OMM) over 1 year.
View Article and Find Full Text PDFA Clinical Comparative Study of Dexmedetomidine, Dexamethasone, and Clonidine as Adjuvants to Local Anesthetics in Supraclavicular Brachial Plexus Blocks.
Cureus
December 2024
Anaesthesiology, Gajra Raja Medical College, Jaya Arogya Group of Hospitals, Gwalior, IND.
Introduction: The brachial plexus block is one of the peripheral blocks, beneath which the majority of upper limb surgical procedures are carried out. During upper limb surgery, a supraclavicular nerve block is an excellent substitute for general anesthesia.
Aim: This is a clinical comparative study of dexmedetomidine, dexamethasone, and clonidine as adjuvants to local anesthetics in supraclavicular brachial plexus block.
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