The physician-administrator team can take all that is good from the physician practice management company (PPMC) model and apply a variation of self-financing called a "tithe" in order to facilitate their group's growth. Essentially, a group can create its own PPMC for local consolidation purposes, contracting with payers, spreading risk contracts over a larger base of providers, getting access to ancillary services, centralized business office services, bulk purchasing and many other of the advantages extolled by PPMCs. Organization has value, especially in times of specific industry consolidation. Although most everyone agrees that the medical industry is undergoing tremendous consolidation, consolidation will not likely occur "top-down." Rather, it will occur more slowly--one group at a time, one locale at a time. If a group positions itself as a local consolidation leader and amalgamates other groups onto its "token ring," then all participants--especially those who initiate this consolidation--will reap the benefits.
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Sci Rep
January 2025
Universidade Federal do Pará, Belém, 66075-110, Brazil.
In Brazil, health policies implemented over the last three decades have enabled rapid testing for HIV to be made available in primary health care services. However, although these policies are national, the implementation of actions is not uniform, as they depend on the local management of local health systems. In this context, the study identified the proportion of women from sexual minorities who had never tested for HIV and the factors associated with access, in a Metropolitan Region of the Brazilian Amazon.
View Article and Find Full Text PDFProg Biophys Mol Biol
January 2025
Department of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China; Metabolic Vascular Disease Key Laboratory of Sichuan Province, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, China; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases) Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, China; Department of General Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China. Electronic address:
Vinculin, a crucial adhesion plaque protein, plays a significant role in cell morphology and tissue development. Dysregulation of focal adhesion proteins has been linked to numerous diseases, including cardiovascular conditions, gastrointestinal disorders, and cancer. Recent studies increasingly highlight vinculin's involvement in the progression of these diseases; however, a comprehensive review remains lacking.
View Article and Find Full Text PDFRadiother Oncol
January 2025
The Royal Marsden NHS Foundation Trust, Sutton, UK; The Institute of Cancer Research, Sutton, UK.
Background: While SBRT to NSBM has become common, particularly in the oligometastatic population, the approach to treating non-spine bone metastases (NSBM) with stereotactic body radiotherapy (SBRT) varies widely across institutions and clinical trial protocols. We present a comprehensive systematic review of the literatures to inform practice recommendations on behalf of the International Stereotactic Radiosurgery Society (ISRS).
Methods: A systematic literature review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
Viruses
January 2025
Department of Ophthalmology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, China.
COVID-19, caused by SARS-CoV-2, has presented formidable challenges to global health since its emergence in late 2019. While primarily known for respiratory symptoms, it can also affect the ocular surface. This review summarizes the effects of SARS-CoV-2 on ocular surface immunity and inflammation, focusing on infection mechanisms, immune responses, and clinical manifestations.
View Article and Find Full Text PDFBMC Cancer
January 2025
Department of Brachytherapy, Saint John's Cancer Center, Lublin, Poland.
Background: The current standard of care (SoC) for patients with extensive-disease small-cell lung cancer (ED-SCLC) is chemo-immunotherapy. The efficacy of radiotherapy (RT) for chest consolidation has been established for patients with ED-SCLC who have responded to chemotherapy. There is a lack of data on incorporating RT as chest consolidation and metastasis-directed therapy for ED-SCLC.
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