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The NADH-dependent flavin reductase ThdF follows an ordered sequential mechanism though crystal structures reveal two FAD molecules in the active site.
J Biol Chem
December 2024
Structural Biochemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany. Electronic address:
Two-component flavin-dependent monooxygenases are of great interest as biocatalysts for the production of pharmaceuticals and other relevant molecules, as they catalyze chemically important reactions such as hydroxylation, epoxidation and halogenation. The monooxygenase components require a separate flavin reductase, which provides the necessary reduced flavin cofactor. The tryptophan halogenase Thal from Streptomyces albogriseolus is a well-characterized two-component flavin-dependent halogenase.
View Article and Find Full Text PDFNew particle formation from isoprene under upper-tropospheric conditions.
Nature
December 2024
Institute for Atmospheric and Earth System Research/Physics, Faculty of Science, University of Helsinki, Helsinki, Finland.
Aircraft observations have revealed ubiquitous new particle formation in the tropical upper troposphere over the Amazon and the Atlantic and Pacific oceans. Although the vapours involved remain unknown, recent satellite observations have revealed surprisingly high night-time isoprene mixing ratios of up to 1 part per billion by volume (ppbv) in the tropical upper troposphere. Here, in experiments performed with the CERN CLOUD (Cosmics Leaving Outdoor Droplets) chamber, we report new particle formation initiated by the reaction of hydroxyl radicals with isoprene at upper-tropospheric temperatures of -30 °C and -50 °C.
View Article and Find Full Text PDFNonheme iron catalyst mimics heme-dependent haloperoxidase for efficient bromination and oxidation.
Sci Adv
December 2024
Department of Chemistry, The Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong, China.
The [Fe]/HO oxidation system has found wide applications in chemistry and biology. Halogenation with this [Fe]/HO oxidation protocol and halide (X) in the biological system is well established with the identification of heme-iron-dependent haloperoxidases. However, mimicking such halogenation process is rarely explored for practical use in organic synthesis.
View Article and Find Full Text PDFRecent Progress in Steroid C(sp)-H Functionalization.
Chem Rec
December 2024
Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1 K, 15-245, Bialystok, Poland.
Selective C-H functionalization methods could provide a valuable tool for synthesizing different steroid derivatives, which is essential not only in contexts of developing novel synthetic methodology but also as a direct way for gathering the analogues needed for studying the structure-activity relationships and obtaining biologically active compounds. The review discusses recent examples of steroid C-H functionalization to various C-X derivatives (C-O, C-C, C-N, C-S, and C-halogen) using available methods emphasizing their scope and limitations.
View Article and Find Full Text PDFPorous pillar[6]arene-based polymers for reversible iodine capture.
Nanoscale Adv
November 2024
State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology Beijing 100850 P. R. China
Iodine in nuclear waste can cause serious environment pollution and health risks, and has thus driven more development of materials for iodine capture. Herein, a novel porous pillar[6]arene-based polymer (P-P6APs) was easily prepared as a supramolecular adsorbent for iodine a one-step crosslinking reaction between per-hydroxylated pillar[6]arene and decafluorobiphenyl. Nitrogen adsorption tests demonstrated that this material possessed a satisfactory surface area ( = 366 m g) and pore diameter (3.
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