In this paper we describe techniques for measuring the dimensions and position reproducibility of an 192Ir brachytherapy stepping source. Measurements were carried out using a 0.25x10x152 mm3 collimator placed in front of a detector of our own design. The brachytherapy source was translated past the collimator in 0.025 mm increments using a stepper motor. The source was found to be 3.58 mm long and 0.69 mm wide, which is in good agreement with the manufacturer's values of 3.5x0.6 mm2. The source position was reproducible to within 0.12 mm.
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http://dx.doi.org/10.1118/1.598874 | DOI Listing |
Phys Med Biol
October 2024
Medical Physics Unit, Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Relative biological effectiveness (RBE) differs between radiation qualities. However, an RBE of 1.0 has been established for photons regardless of the wide range of photon energies used clinically, the lack of reproducibility in radiobiological studies, and outdated reference energies used in the experimental literature.
View Article and Find Full Text PDFAppl Radiat Isot
June 2021
Centro de Desenvolvimento da Tecnologia Nuclear, Comissão Nacional de Energia Nuclear, Belo Horizonte, Brazil; Nanobiomedical Research Group, Departamento de Física, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Irradiation of tumor cell lines is a useful way to investigate the effects of ionizing radiation on biological molecules. We designed an easy and reproducible approach for in vitro experimental high dose rate brachytherapy, which was simulated by a Monte Carlo code and dosimetrically characterized by experimental methods to evaluate the correspondence between planned doses and doses absorbed by the cells. This approach is an acrylic platform containing T25 tissue culture flasks and multiwell tissue culture plates.
View Article and Find Full Text PDFBrachytherapy
August 2021
Australian Radiation Protection and Nuclear Safety Agency, Yallambie, Australia.
Purpose: The purpose of the study was to establish, using a retrospective analysis of existing hospital records, the long-term stability and accuracy of a high-dose-rate brachytherapy well chamber. This should be assessed to determine reliability and appropriate calibration frequency. The accrual of long-term data that demonstrates the stability of our chamber may inform others of the performance they might expect from similar equipment.
View Article and Find Full Text PDFJ Contemp Brachytherapy
February 2020
Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Purpose: To design a novel high-dose-rate intracavitary applicator which may lead to enhanced dose modulation in the brachytherapy of gynecological cancers.
Material And Methods: A novel brachytherapy applicator, auxiliary equipment and quality control phantom were modeled in SketchUp Pro 2017 modeling software and printed out from a MakerBot Replicator Z18 three-dimensional printer. As a printing material polylactic acid (PLA) filament was used and compensator materials including aluminum, stainless-steel and Cerrobend alloy were selected according to their radiation attenuation properties.
Phys Med
March 2020
Departamento de Ciências Radiológicas DCR, Universidade do Estado do Rio de Janeiro (UERJ), RJ, Rio de Janeiro, Brazil.
For the small animal radiation research platform (SARRP) with X-ray beams in the medium energy range (tube operating voltage at 220 kVp), reference dosimetry is based on the AAPM TG-61 recommendations following the in-phantom method. The objective of this study was to evaluate the feasibility of the Fricke solution as a dosimeter to determine the absorbed dose to water. Feasibility studies at this X-ray energy range are not widely available.
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