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Background: Pseudomyxoma peritonei (PMP) is an unusual clinical condition typically presenting with widespread mucinous neoplastic lesions within the peritoneum resulting in gelatin material-rich ascites. It was first described by Werth in 1884. Ever since, its clinical presentation, definition, site of origin, and prognosis have been a subject of debate.

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Neoadjuvant Intraperitoneal Chemotherapy in Patients with Pseudomyxoma Peritonei-A Novel Treatment Approach.

Cancers (Basel)

August 2020

Department of Regional Cancer therapy, Peritoneal Surface Malignancy Center, Kishiwada, Tokushukai Hospital, Kishiwada, Osaka 596-0042, Japan.

Article Synopsis
  • Neoadjuvant intravenous chemotherapy for pseudomyxoma peritonei (PMP) has shown limited effectiveness, prompting a study of neoadjuvant intraperitoneal chemotherapy as an alternative.
  • In a phase II study, patients unsuitable for primary surgery received laparoscopic HIPEC and subsequent intraperitoneal treatments, resulting in a high qualification rate for subsequent surgery and a significant percentage of complete tumor removal.
  • Although the treatment led to positive outcomes like tumor regression and low complication rates, further research is needed to determine its impact on long-term survival for PMP patients.
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Pseudomyxoma peritonei causes marked accumulation of jelly-like ascites in the peritoneal cavity. Removal of much mucinous ascites by irrigating the cavity appears to be an effective treatment. We describe a patient who underwent the irrigation with sodium bicarbonate solution and developed critical alkalemia.

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