The largest occurrence of carbon monoxide poisoning in Britain demonstrates the potential for mass accidental poisoning. It emphasises the need for strict public health controls and the importance of good liaison between emergency services to ensure that such events are quickly recognised and that the necessary resources are organised.
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http://dx.doi.org/10.1136/emj.17.1.38 | DOI Listing |
Science
January 2025
Redox and Metalloprotein Research Group, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
In the ancient microbial Wood-Ljungdahl pathway, carbon dioxide (CO) is fixed in a multistep process that ends with acetyl-coenzyme A (acetyl-CoA) synthesis at the bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase complex (CODH/ACS). In this work, we present structural snapshots of the CODH/ACS from the gas-converting acetogen , characterizing the molecular choreography of the overall reaction, including electron transfer to the CODH for CO reduction, methyl transfer from the corrinoid iron-sulfur protein (CoFeSP) partner to the ACS active site, and acetyl-CoA production. Unlike CODH, the multidomain ACS undergoes large conformational changes to form an internal connection to the CODH active site, accommodate the CoFeSP for methyl transfer, and protect the reaction intermediates.
View Article and Find Full Text PDFNicotine Tob Res
January 2025
Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN.
Introduction: Hormonal contraceptives (HCs), which contain synthetic forms of estrogen (i.e., ethinyl estradiol) and/or progesterone (i.
View Article and Find Full Text PDFClin Radiol
January 2025
Department of Nuclear Medicine, China-Japan Friendship Hospital, Beijing, 100029, China. Electronic address:
Aim: To evaluate the correlation between semi-quantitative analyses and visual scores of pulmonary perfusion Single Photon Emission Computed Tomography (SPECT)/ Computed Tomography (CT) imaging and pulmonary function test parameters (PFTs) in patients with interstitial lung diseases (ILDs).
Materials And Methods: This retrospective study included 35 patients with ILDs from China-Japan Friendship Hospital between January 2020 and December 2022. All patients underwent pulmonary perfusion SPECT/CT imaging and a pulmonary function test.
Nat Chem Biol
January 2025
Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Diverse bacteria and archaea use atmospheric CO as an energy source for long-term survival. Bacteria use [MoCu]-CO dehydrogenases (Mo-CODH) to convert atmospheric CO to carbon dioxide, transferring the obtained electrons to the aerobic respiratory chain. However, it is unknown how these enzymes oxidize CO at low concentrations and interact with the respiratory chain.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
January 2025
Engine Testing Laboratory, Department of Automobile Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India.
The present work emphasizes the viability of methyl ester production, characterization, and utilization of third-generation biofuel from Chlorella vulgaris microalgae. The presence of methyl oleate (CHO) in the Chlorella vulgaris methyl ester (CVME) algae signifies the existence of higher oxidation stability and prone to peroxidation. The single-stage transesterified CVME algae contains majorly (C-H) functional group trailed by (C = O), (C-O), (O-CH), (C-O-C) with the elemental compositions of 66.
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