AI Article Synopsis
- The study examined how 9-cis-retinoic acid is processed and distributed in hairless rats, as there's limited understanding of its pharmacokinetics.
- After giving a single oral dose of 30 mg/kg, the drug and five metabolites were found in the rat's plasma.
- The drug was quickly distributed in various organs, remaining detectable in the skin for up to 168 hours, while being undetectable in other organs and plasma after 48 hours.
Article Abstract
The biotransformation and tissue distribution of 9-cis-retinoic acid was investigated in hairless rats. Indeed, only limited information is available about the pharmacokinetics of 9-cis-retinoic acid. Assuming that the target site for retinoids is the skin, tissue distribution study is therefore particularly justified. Following single oral administration of 30 mg/kg of 9-cis-retinoic acid, the parent drug and five metabolites were detected in plasma. Additionally, concentrations of 9-cis-retinoic acid and metabolites were determined in the skin and seven other tissues. The distribution of 9-cis-retinoic acid was rapid in all of the organs studied (T(max)
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| http://dx.doi.org/10.1159/000029904 | DOI Listing |
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