Purpose: To report evidence of many human papillomavirus types occurring in a solitary syringoma clinically appearing as a papilloma.
Methods: A 57-year-old man presented with a 10-year history of an upper eyelid tumor. Histopathology, human papillomavirus-nested polymerase chain reaction, human papillomavirus-DNA cloning into vector pCR2.1, sequencing, and computer-assisted evaluation were performed.
Results: Histopathology demonstrated a solitary benign syringoma. HPV-20 and HPV-23 were present in one clone each, and HPV-5-related HPV-DL332 was present in 9 clones.
Conclusion: Many human papillomavirus types may be detected in an ocular syringoma.
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