Recent studies of genetically engineered animals have established a role for the angiotensin II (AT2) receptor in cardiovascular, renal and central functions, as well as in developmental processes. This review summarizes new insights into major AT2 signaling pathways--activation of protein phosphatases, the nitric oxide-cGMP system and phospholipase A2--which have been related to specific cellular responses or functions of this receptor.
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Int J Mol Sci
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Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
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Wolfson Sensory, Pain and Regeneration Centre, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK. Electronic address:
Angiotensin II is well known to have an important influence on blood pressure, mediated via the angiotensin II type 1 receptor (AT1R), but more recent studies have shown that angiotensin II may play an important additional role in eliciting pain via a distinct action at the angiotensin II type 2 receptor (AT2R). Signalling pathways that link activation of AT2R to a sensation of pain are, however, incompletely understood. Here we use rodent inflammatory pain models to confirm that selective activation of AT2R triggers aversive responses, and that these are abolished by either antagonism or genetic deletion of AT2R.
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