An exceptionally large repeating unit has been proposed for one of the two O-specific polysaccharides of the lipopolysaccharide from Pseudomonas (Burkholderia) caryophylli, which is a homopolymer of the sugar caryose. This proposal is based on the unusual acetylation pattern of the carbohydrate (shown in the picture), as determined from the presence of eight independent spin systems observed by NMR spectroscopy. A=acetylated, D=non-acetylated caryose monomer.

Download full-text PDF

Source

Publication Analysis

Top Keywords

lipopolysaccharide pseudomonas
8
pseudomonas burkholderia
8
burkholderia caryophylli
8
acetyl substitution
4
substitution o-specific
4
o-specific caryan
4
caryan lipopolysaccharide
4
caryophylli leads
4
leads block
4
block pattern
4

Similar Publications

Unlabelled: is a high-priority organism for the development of new antibacterial treatments. We found that the antimalarial medication mefloquine (MFQ) permeabilized the bacterial cell membrane of , decreased membrane fluidity, and caused physical injury to the membrane. MFQ also maintained activity across different pH conditions (PH range 5-8).

View Article and Find Full Text PDF

A chemical investigation of the soft coral sp. and the sponge sp. from the South China Sea led to the isolation of five steroids, including two new compounds ( and ) and one known natural product ().

View Article and Find Full Text PDF

Antimicrobial peptides (AMPs) are key components of innate immunity across all domains of life. Natural and synthetic AMPs are receiving renewed attention in efforts to combat the antimicrobial resistance (AMR) crisis and the loss of antibiotic efficacy. The gram-negative pathogen Pseudomonas aeruginosa is one of the most concerning infecting bacteria in AMR, particularly in people with cystic fibrosis (CF) where respiratory infections are difficult to eradicate and associated with increased morbidity and mortality.

View Article and Find Full Text PDF

A Phage-Based Approach to Identify Antivirulence Inhibitors of Bacterial Type IV Pili.

Microb Biotechnol

January 2025

Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, USA.

The increasing threat of antibiotic resistance underscores the urgent need for innovative strategies to combat infectious diseases, including the development of antivirulants. Microbial pathogens rely on their virulence factors to initiate and sustain infections. Antivirulants are small molecules designed to target virulence factors, thereby attenuating the virulence of infectious microbes.

View Article and Find Full Text PDF

Virus Association with Bacteria and Bacterial Cell Components Enhance Virus Infectivity.

Food Environ Virol

January 2025

Division of Agriculture, Department of Food Science, University of Arkansas, 1371 West Altheimer Dr, Fayetteville, AR, 72704, USA.

The transmission and infection of enteric viruses can be influenced by co-existing bacteria within the environment and host. However, the viral binding ligands on bacteria and the underlying interaction mechanisms remain unclear. This study characterized the association of norovirus surrogate Tulane virus (TuV) and murine norovirus (MNV) as well as the human enteric virus Aichi virus (AiV) with six bacteria strains (Pantoea agglomerans, Pantoea ananatis, Bacillus cereus, Enterobacter cloacae, Exiguobacterium sibiricum, Pseudomonas spp.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!