Objective: To assess the role of beta cell failure in the development of autonomic dysfunction in patients with coronary artery disease.
Design: Autonomic function was measured by standard clinical methods and by heart rate variability in 24 type II diabetic and 24 non-diabetic subjects with coronary artery disease. Quantitative estimates of pancreatic beta cell function (%beta) and insulin resistance were made from basal plasma glucose and insulin concentrations using a computer solved model. Fasting proinsulin levels provided an independent measure of beta cell function.
Results: The circadian rhythm of sympathovagal balance (ratio of low to high frequency spectral components of heart rate variability) was significantly attenuated in patients with below median (%beta
Conclusions: The data are consistent with the hypothesis that beta cell failure plays a pathogenic role in the development of autonomic dysfunction in patients with coronary artery disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1729315 | PMC |
| http://dx.doi.org/10.1136/heart.83.2.210 | DOI Listing |
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