AI Article Synopsis
- The study examined how genetics and the environment affect migraine with aura (MA) using a large twin sample from the Danish Twin Register, consisting of over 5,000 pairs.
- In monozygotic (MZ) twins, the concordance rate for MA was 34%, significantly higher than the 12% found in same-gender dizygotic (DZ) twins, suggesting a strong genetic component.
- Despite the genetic influence, the less-than-100% concordance in MZ pairs indicates that environmental factors also play a role, as shown by similar recurrence risks in non-twin siblings and DZ pairs.
Article Abstract
We studied the genetic and environmental influence on migraine with aura (MA) by analysing a twin population. The twin sample consisted of 2,026 monozygotic (MZ) pairs and 3,334 same-gender dizygotic (DZ) pairs recruited from the population-based Danish Twin Register. A total of 211 pairs were identified, of whom 77 were MZ and 134 were DZ. The pairwise concordance rate was significantly higher in MZ-than in DZ-pairs, i.e. 34% and 12%, respectively, emphasizing the importance of genetic factors in MA. However, environmental factors are also important, as the pair wise concordance rate was less than 100% in MZ-pairs. Similarly, the recurrence risk of MA was 50% in MZ- and 21% in DZ-pairs which was a significant difference. In non-twin siblings, the recurrence risk of MA is 27%, which is similar to the recurrence risk in DZ-pairs. This indicates that MA is not developed due to specific environmental factors shared by the twins.
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