The Tower of London (TOL) task is widely used as a neuropsychological test of planning. Relatively little is known of the cognitive components of the task, and in particular the role of memory in performance. The current studies on normal adults looked at the role of verbal and spatial working memory in the TOL. The effects of verbal and visuospatial dual-task manipulations on TOL performance were examined in an experiment with 36 participants. Both verbal and visuospatial executive secondary tasks caused poorer performance on the TOL; however, concurrent articulatory suppression enhanced performance. The results suggest that executive and spatial components are important in the task, and raise questions about the role of preplanning in the TOL.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1080/741944066 | DOI Listing |
J Neurophysiol
January 2025
Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee WI, USA.
The hippocampus has a known role in learning and memory, with the ventral subregion supporting many learning tasks involving affective responding, including fear conditioning. Altered neuronal intrinsic excitability reflects experience-dependent plasticity that supports learning-related behavioral changes. Such changes have previously been observed in the dorsal hippocampus following fear conditioning, but little work has examined the effect of fear conditioning on ventral hippocampal intrinsic plasticity.
View Article and Find Full Text PDFDigit Biomark
December 2024
Electrical and Computer Engineering, Western Michigan University, Kalamazoo, MI, USA.
Introduction: This research is focused on early detection of Alzheimer's disease (AD) using a multiscale feature fusion framework, combining biomarkers from memory, vision, and speech regions extracted from magnetic resonance imaging and positron emission tomography images.
Methods: Using 2D gray level co-occurrence matrix (2D-GLCM) texture features, volume, standardized uptake value ratios (SUVR), and obesity from different neuroimaging modalities, the study applies various classifiers, demonstrating a feature importance analysis in each region of interest. The research employs four classifiers, namely linear support vector machine, linear discriminant analysis, logistic regression (LR), and logistic regression with stochastic gradient descent (LRSGD) classifiers, to determine feature importance, leading to subsequent validation using a probabilistic neural network classifier.
Cureus
December 2024
Division of Internal Medicine, Miyagi Central Hospital, Sendai, JPN.
Several neurological conditions, including transient global amnesia (TGA), may present an isolated sudden-onset temporary amnestic symptom. TGA is a benign, self-remitting neurological condition associated with hippocampal dysfunction. Meanwhile, certain other neurological conditions, such as cerebral ischemic stroke and hippocampal epilepsy, require appropriate therapeutic interventions.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Department of Neurological Function Examination, Affiliated Hospital of Hebei University, Baoding, China.
Background: Lower-grade glioma (LGG) exhibits significant heterogeneity in clinical outcomes, and current prognostic markers have limited predictive value. Despite the growing recognition of histone modifications in tumor progression, their role in LGG remains poorly understood. This study aimed to develop a histone modification-based risk signature and investigate its relationship with drug sensitivity to guide personalized treatment strategies.
View Article and Find Full Text PDFNeuropsychopharmacol Rep
March 2025
Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Contradictory results for the association between metformin intake and changes in cognitive function have been reported. We attempted to overview systematic reviews and meta-analyses showing the role of metformin, as mono or combination therapy, in cognitive performance alterations among patients with type 2 diabetes mellitus (T2DM) and to determine the quality of the evidence as well. To find the English-written reviews, a literature search was conducted on PubMed, Web of Science, Scopus, Cochrane Library, Trip, and Google Scholar by May 1, 2023.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!