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Genetic factors regulating Plasmodium falciparum gametocytogenesis identified by phenotypic screens.
Sci Rep
December 2024
Center for Global Health and Inter-Disciplinary Research, College of Public Health, University of South Florida, Tampa, FL, USA.
Successful transmission of Plasmodium falciparum from one person to another relies on the complete intraerythrocytic development of non-pathogenic sexual gametocytes infectious for anopheline mosquitoes. Understanding the genetic factors that regulate gametocyte development is vital for identifying transmission-blocking targets in the malaria parasite life cycle. Toward this end, we conducted a forward genetic study to characterize the development of gametocytes from sexual commitment to mature stage V.
View Article and Find Full Text PDFIncreased Anion Exchanger-1 (Band 3) on the Red Blood Cell Membrane Accelerates Scavenge of Nitric Oxide Metabolites and Predisposes Hypertension Risks.
Function (Oxf)
December 2024
The Laboratory of Immunogenetics, Department of Medical Research, MacKay Memorial Hospital, Tamsui, New Taipei City, Taiwan.
The erythrocyte membrane is highly specialized with ∼one million anion exchanger-1 (AE1) per cell for rapid membrane permeation of HCO3-(aq), as most blood CO2(g) is carried in this hydrated anionic form. People with the GP.Mur blood type have more AE1 on their erythrocyte membrane, and they excrete CO2(g) more efficiently.
View Article and Find Full Text PDFPopulation genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background.
Nat Commun
December 2024
School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
The emergence of Plasmodium falciparum parasites resistant to artemisinins compromises the efficacy of Artemisinin Combination Therapies (ACTs), the global first-line malaria treatment. Artemisinin resistance is a complex genetic trait in which nonsynonymous SNPs in PfK13 cooperate with other genetic variations. Here, we present population genomic/transcriptomic analyses of P.
View Article and Find Full Text PDFCritical role of Babesia bovis spherical body protein 3 in ridge formation on infected red blood cells.
PLoS Pathog
November 2024
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Article Synopsis
- * The study focused on SBP3, a protein exported by the parasite, which plays a crucial role in the formation of surface protrusions on infected red blood cells that help the parasite adhere to blood vessel cells.
- * Knocking down SBP3 resulted in hindered parasite growth, fewer adhesion sites, and fewer protrusions, indicating its essential function for the parasite's survival and interaction with the host's cells.
The histone methyltransferase SET10 participates in a chromatin modulation network crucial for intraerythrocytic development.
mSphere
November 2024
Division of Cellular and Applied Infection Biology, RWTH Aachen University, Aachen, Germany.
The lifecycle progression of the malaria parasite requires precise tuning of gene expression including histone methylation. The histone methyltransferase SET10 was previously described as an H3K4 methyltransferase involved in gene regulation, making it a prominent antimalarial target. In this study, we investigated the role of SET10 in the blood stages of in more detail, using tagged SET10-knockout (KO) and -knockdown (KD) lines.
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