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Venetoclax and azacitidine in combination with homoharringtonine, cytarabine, and aclarubicin for salvage therapy of relapsed/refractory T cell acute lymphoblastic leukemia.
Int J Hematol
January 2025
Department of Hematology, The 920th Hospital of Joint Logistics Support Force, No.212, Da Guan Road, Xishan District, Kunming, 650100, Yunnan, China.
Background: The treatment of relapsed/refractory T cell acute lymphoblastic leukemia (R/R T-ALL) is a significant challenge in hematologic oncology, and no standard salvage treatment plan exists. Both Chinese and international clinical guidelines recommend combination chemotherapy including venetoclax.
Methods: Efficacy and safety of venetoclax, azacitidine, homoharringtonine, cytarabine, and aclarubicin (VA-HAA) combination therapy were retrospectively analyzed in 3 patients with R/R T-ALL at the Department of Hematology, 920th Hospital of the Joint Logistics Support Force, Chinese People's Liberation Army.
Generation of ribosomal protein S1 mutants for improving of expression of difficult to translate mRNAs.
Appl Microbiol Biotechnol
January 2025
Department of Bioproducts and Biosystems, Aalto University, Espoo, Finland.
Metagenomes present a source for novel enzymes, but under 1% of environmental microbes are cultivatable. Because of its useful properties, Escherichia coli has been used as a host organism in functional genomic screens. However, due to differing expression machineries in the expression host compared to the source organism of the DNA sequences, screening outcomes can be biased.
View Article and Find Full Text PDFGlobal transcriptome changes during growth of a novel Penicillium coffeae isolate on the wheat stripe rust fungus, Puccinia striiformis f. sp. tritici.
Fungal Genet Biol
January 2025
Research School of Biology, The Australian National University, 134 Linnaeus Way, Canberra, ACT 2601, Australia. Electronic address:
Wheat stripe rust caused by the fungus Puccinia striiformis f. sp. tritici (Pst) is currently the most destructive disease of wheat.
View Article and Find Full Text PDFGenome-resolved adaptation strategies of to changing conditions in the Chesapeake and Delaware Bays.
Appl Environ Microbiol
January 2025
Department of Biological Sciences, Clemson University, Clemson, South Carolina, USA.
Unlabelled: The abundant and metabolically versatile aquatic bacterial order, , influences marine biogeochemical cycles. We assessed metagenome-assembled genome (MAG) abundance, estimated growth rates, and potential and expressed functions in the Chesapeake and Delaware Bays, two important US estuaries. Phylogenomics of draft and draft/closed genomes from this study and others placed 46 nearly complete MAGs from these bays into 11 genera, many were not well characterized.
View Article and Find Full Text PDFTranscriptome Analysis Unveils Molecular Mechanisms of Acaricide Resistance in Two-Spotted Spider Mite Populations on Hops.
Int J Mol Sci
December 2024
Department of Entomology, Pennsylvania State University, University Park, PA 16802, USA.
Broad-spectrum crop protection technologies, such as abamectin and bifenthrin, are globally relied upon to curb the existential threats from economic crop pests such as the generalist herbivore Koch (TSSM). However, the rising cost of discovering and registering new acaricides, particularly for specialty crops, along with the increasing risk of pesticide resistance development, underscores the urgent need to preserve the efficacy of currently registered acaricides. This study examined the overall genetic mechanism underlying adaptation to abamectin and bifenthrin in populations from commercial hop fields in the Pacific Northwestern region of the USA.
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