Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s004030050464 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Simplified biomimetic peptide-based vehicle for enhanced tumor penetration and rapid enzyme-induced drug release.
J Colloid Interface Sci
January 2025
State Key Laboratory of Metastable Materials Science and Technology, Nano-biotechnology Key Lab of Hebei Province, Applying Chemistry Key Lab of Hebei Province, Heavy Metal Deep-Remediation in Water and Resource Reuse Key Lab of Hebei, Yanshan University, Qinhuangdao 066004, China. Electronic address:
Various nanodrug vehicles were well-designed with complicated functions for tumor therapy. However, the unsatisfactory tumor delivery efficiency and uncertain off-target release became the stumbling block of the nanodrugs on the way to the clinic. Inspired by efficient tumor targeting ability of albumin, we reported a simplified biomimetic peptide-based vehicle synthesized by copolymerizing L-glutamyl-L-lysine unit (EK dimer, an intrinsic surface peptide pair from albumin) with L-phenylalanine (F) to encapsulate doxorubicin (Dox).
View Article and Find Full Text PDFBackground: Blood exchange experiments in heterochronic parabionts or heterochronic plasma transfer have revealed that age-associated changes in blood composition contribute to neurogenesis and cognitive impairment in the elderly, and multiple blood-born pro-aging factors have been identified as causal factors to accelerate age-dependent brain changes. We previously demonstrate that PDGF-BB secreted by pre-osteoclasts in bone mediates cerebrovascular impairment during aging, but the bone-derived PDGF-BB in Alzheimer's disease (AD) progression is still uncertain.
Methods: MCI patients and two transgenic AD mouse models, App-ps1 and 5XFAD, were used to evaluated PDGF-BB level by ELISA measurement.
Developing Topics.
Alzheimers Dement
December 2024
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Cardiometabolic disorders represent a pressing public health challenge and confer heightened susceptibility to age-related cognitive decline, including increased risk of developing Alzheimer's disease (AD). There is a strong genetic component underlying risks for these conditions, and human Genome-Wide Association Studies (GWAS) have associated the PPP1R3B genetic locus with both cardiometabolic dysfunction and AD. PPP1R3B protein is primarily expressed in liver hepatocytes, regulating liver glycogen metabolism.
View Article and Find Full Text PDFBackground: T cell mediated immunity is reported to play a pathogenic role in cardiac allograft vasculopathy (CAV) in heart transplant (HTx) patients. However, peripheral blood CD8 T cells have not been previously characterized in CAV. This study aimed to identify potentially pathogenic circulating CD8 T cell populations in high grade CAV patients using cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq).
View Article and Find Full Text PDFPINK1 modulates Prdx2 to reduce lipotoxicity-induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction.
Clin Transl Med
January 2025
Key Laboratory For Organ Failure Research, Ministry of Education of the People's Republic of China, Guangzhou, China.
Introduction: Heart failure with preserved ejection fraction (HFpEF) is a complex condition characterized by metabolic dysfunction and myocardial lipotoxicity. The roles of PTEN-induced kinase 1 (PINK1) and peroxiredoxin-2 (Prdx2) in HFpEF pathogenesis remain unclear.
Objective: This study aimed to investigate the interaction between PINK1 and Prdx2 to mitigate cardiac diastolic dysfunction in HFpEF.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!