AI Article Synopsis
- Siderophores are crucial for microbial growth and pathogenicity by helping microbes acquire iron from their environment, even when iron is scarce.
- Tremendous advancements have been made in understanding siderophore structures and the mechanisms involved in their transport across microbial membranes.
- The development of siderophore-drug conjugates offers a promising strategy for targeted drug delivery, particularly against drug-resistant microbial strains.
Article Abstract
Siderophores (microbial iron chelators) play an extremely important role in microbial pathogenicity. Microbial uptake of siderophore-iron complexes through active transport systems allow microbes to survive and proliferate even under iron deficient environments during invasion of a host. Due to their structural complexity, unique iron (III) chelation, acquisition properties, and their therapeutic potential, siderophores have attracted much attention in a broad range of disciplines. Tremendous progress has been made in siderophore syntheses, in determination of the structures and functions of outer membrane receptors (e.g. FhuA and FepA), and in the mechanistic insight into siderophore-iron-mediated active transport processes. One of the important practical applications of this active transport system is development of species-selective active drug transport (the Trojan Horse approach) to potentially treat infections due to drug resistant strains of microbes. Siderophore-drug conjugates have shown great potential in active drug delivery to target pathogenic microbes.
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| http://dx.doi.org/10.2174/0929867003375353 | DOI Listing |
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