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[Will a glaucoma drug revolutionize the treatment of androgenetic alopecia? On drug repurposing, when the side effect becomes a desired therapeutic outcome].
Postepy Biochem
December 2024
Department of Biochemistry and Nutrition, Centre for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland.
Prostaglandins are hormones found in almost all mammalian tissues. As signaling molecules, they play a key role in the regulation of many physiological processes, including hair growth cycle. The article describes the history of the discovery of prostaglandins, including the work of Professor Ryszard Gryglewski – the discoverer of prostacyclin.
View Article and Find Full Text PDFPopulation pharmacokinetics of selexipag for dose selection and confirmation in pediatric patients with pulmonary arterial hypertension.
CPT Pharmacometrics Syst Pharmacol
December 2024
Department of Clinical Pharmacology & Pharmacometrics, Janssen-Cilag S.p.A., Milan, Italy.
Article Synopsis
- Selexipag is an oral medication used to treat pulmonary arterial hypertension (PAH) in adults, but there are currently no approved treatments targeting this pathway for children.
- The researchers aimed to establish appropriate dosing for pediatric patients by using a pharmacokinetic model derived from adult data, creating weight-based dosing groups with specific starting and maximum doses for different age brackets.
- A clinical study involving 63 pediatric PAH patients showed that the adjusted doses for children resulted in similar drug exposure levels to the adult population, confirming the dosing regimen's safety and efficacy for kids aged 2 to under 18.
Prostacyclin Synthase Deficiency Leads to Exacerbation or Occurrence of Endothelium-Dependent Contraction and Causes Cardiovascular Disorders Mainly via the Non-TxA Prostanoids/TP Axis.
Circ Res
August 2024
Cardiovascular Research Center (J.G., Yingbi Zhou, K.X., J.L., X.C., G.Y., X.S., Y.X., D.H., B.L.), Shantou University Medical College, China.
Article Synopsis
- - Prostaglandin I, produced by COX in endothelial cells, can cause vasodilation in some blood vessels while paradoxically leading to endothelium-dependent constriction (EDC) in others, particularly in diseases like hypertension, though the effects of PGIS deficiency on EDC and related cardiovascular issues are not well understood.
- - The study utilized various mouse models, including wild-type and genetically modified knockouts, to measure the impact of PGIS deficiency and assess vasomotor responses, indicating alterations in nitric oxide production and signaling.
- - Results showed that PGIS deficiency worsened EDC and led to increases in blood pressure and cardiac issues over time, but additional removal of the thromboxane receptor improved vascular function and reduced
Generation of monoclonal antibody against 6-Keto PGF and development of ELISA for its quantification in culture medium.
Biochem Biophys Rep
September 2024
Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.
Prostacyclin or prostaglandin I (PGI), a metabolite of arachidonic cyclooxygenase pathway, has been demonstrated as an effector of adipocyte differentiation. However, due to its instability in biological fluid, it is difficult to evaluate the role of PGI in regulating adipocyte differentiation in different stages in culture. Therefore, this study aimed to establish a simple and rapid method for the production of monoclonal antibody against 6-Keto PGFα, a stable PGI metabolite, and its quantification to determine the role of PGI in culture medium.
View Article and Find Full Text PDFBackground: Experimental preeclampsia (ePE) has been shown to have worsened outcome from stroke. We investigated the effect of low-dose aspirin, known to prevent preeclampsia, on stroke hemodynamics and outcome, and the association between the vasoconstrictor and vasodilator cyclooxygenase products thromboxane A and prostacyclin.
Methods And Results: Middle cerebral artery occlusion was performed for 3 hours with 1 hour of reperfusion in normal pregnant rats on day 20 of gestation and compared with ePE treated with vehicle or low-dose aspirin (1.
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