The purpose of this study was to evaluate the in vitro cytotoxicity of two metallic and two plastic Thermafil carrier materials, and to separately evaluate the in vitro corrosion behavior of the two metallic carriers. Stainless-steel, Ti-6AI-4V, Polysulfone, and Vectra carriers were evaluated for cytotoxicity using the ISO-recommended agar overlay test. The two metallic carriers were additionally corrosion tested in 0.9% NaCl solution for 174 wk, at 37 degrees C. Elemental analyses of the corrosion solutions were periodically conducted using inductively coupled plasma-mass spectroscopy. Agar overlay results showed that the four carrier materials were not cytotoxic to L929 fibroblasts. Inductively coupled plasma-mass spectroscopy results showed that the metallic materials had small mass loss rates. Scanning electron microscopy showed no evidence of pitting or crevice corrosion.
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