AI Article Synopsis
- The study explores the effectiveness of new compounds called TIBO, which significantly inhibit HIV-1 replication.
- Researchers modified TIBO structures by removing a ring, resulting in a new set of compounds known as TBO.
- Although TBO compounds show less potency than TIBO analogues, they still exhibit notable anti-HIV-1 activity.
Article Abstract
4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1 H)-ones (TIBO), 1, have been shown to significantly inhibit HIV-1 replication, as reported in detail in our prior publications. Since our earlier reports, we have modified the TIBO structures 1 by removing the 5-membered ring of 1, generating 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-ones (TBO), 4, a bicyclic series of compounds. Although compounds 4 possess modest activity when compared to TIBO analogues 1, they clearly demonstrated significant anti-HIV-1 activity.
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| http://dx.doi.org/10.1016/s0968-0896(99)00198-4 | DOI Listing |
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