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[Evaluation of the efficacy of antifibrotic drugs on cell cultures in Salzmann's nodular degeneration].
Vestn Oftalmol
December 2024
Krasnov Research Institute of Eye Diseases, Moscow, Russia.
Unlabelled: Excessive production of extracellular matrix is a key component in the pathogenesis of Salzmann's nodular degeneration (SND). studies of drugs that suppress excessive fibroblast activity may become crucial in developing pathogenetically oriented treatments for SND.
Purpose: This study evaluates the antifibrotic properties of pirfenidone and cyclosporine A (CsA) on cell cultures obtained from patients with SND.
Salzmann Nodular Degeneration in Ocular and Systemic Diseases.
J Clin Med
August 2024
Department of Ophthalmology, District Railway Hospital in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
This review aimed to evidence the predisposing conditions for Salzmann nodular degeneration (SND), where particular attention was paid to its association with ocular and systemic diseases. SND is a rare disease characterized by bluish-white nodules located in the mid-periphery of the cornea, which are otherwise completely clear. SND has been found in association with different systemic and ocular diseases, and it may have unilateral or bilateral presentation.
View Article and Find Full Text PDFResolution of Plaque Keratopathy in a Patient with Atopic Keratoconjunctivitis After Treatment with Leflunomide.
Ocul Immunol Inflamm
December 2024
Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago, Illinois, USA.
Purpose: To report a case of resolution of corneal findings in a patient with atopic keratoconjunctivitis after treatment with leflunomide.
Methods: Case report.
Results: A 57-year-old male presented with ocular signs and symptoms consistent with severe atopic keratoconjunctivitis.
Purpose: To review the atypical development of Salzmann's nodular degeneration (SND) after two cases of laser in situ keratomileusis (LASIK) and one case of photorefractive keratomileusis (PRK), and to highlight the pathophysiology of SND and its treatment.
Methods: Three cases of SND (two following LASIK performed with microkeratomes and one following PRK) were reviewed and Pubmed.gov and internet searches were performed.
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