Evidence has shown that the right choice of tissue volume to be irradiated is much more important for better therapeutic effect than focal dose variation within 50-80 Gy. No relationship between efficacy of postoperative recurrence treatment, on the one hand, and multiplicity of lesions, recurrence ulceration or additional excision of relapsing node, on the other was established. However, lowered radiosensitivity and relatively very high likelihood of tumor dissemination were typical of tumors larger than 3 cm. Radiotherapy for primary tumor did not affect recurrence radiosensitivity, slowed down its development but might promote acceleration of its dissemination.
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