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Clinical characteristics and cause analysis of false-positive results in treponemal testing among patients.
Ann Med
December 2025
Department of Blood Transfusion, Medicine School of Medicine Jinling Hospital Nanjing University, Nanjing, China.
Background: Currently, there is a dearth of systematic research data on the phenomenon of false-positive reactions in treponemal tests. The aim of this study is to analyze the clinical characteristics and influencing factors associated with false-positive treponemal tests in patients, so as to enhance the diagnostic accuracy of syphilis and mitigate misdiagnosis-induced incorrect treatment.
Methods: From January 2017 to December 2023, a total of 759 cases with false-positive results for treponema were screened for blood transfusion, surgery, or other medical interventions at Jinling hospital.
Large Language Model Approach for Zero-Shot Information Extraction and Clustering of Japanese Radiology Reports: Algorithm Development and Validation.
JMIR Cancer
January 2025
Division of Radiology and Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Background: The application of natural language processing in medicine has increased significantly, including tasks such as information extraction and classification. Natural language processing plays a crucial role in structuring free-form radiology reports, facilitating the interpretation of textual content, and enhancing data utility through clustering techniques. Clustering allows for the identification of similar lesions and disease patterns across a broad dataset, making it useful for aggregating information and discovering new insights in medical imaging.
View Article and Find Full Text PDFUrine proteomics defines an immune checkpoint-associated nephritis signature.
J Immunother Cancer
January 2025
Section of Nephrology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Immune checkpoint inhibitor (ICI) therapy is a cornerstone treatment for many cancers, but it can induce severe immunotoxicity, including acute interstitial nephritis (AIN). Currently, kidney biopsy is required to differentiate ICI-AIN from other causes of acute kidney injury (AKI). However, this invasive approach can lead to morbidity, delayed glucocorticoid treatment for patients with AIN, and unnecessarily prolonged suspension of ICI therapy in non-AIN patients.
View Article and Find Full Text PDFThe Practical Implications of Re-Referencing in ERP Studies: The Case of N400 in the Picture-Word Verification Task.
Diagnostics (Basel)
January 2025
Science and Research Centre, School of Electrical Engineering, University of Belgrade, 11000 Belgrade, Serbia.
The selection of an optimal referencing method in event-related potential (ERP) research has been a long-standing debate, as it can significantly influence results and lead to data misinterpretation. Such misinterpretation can produce flawed scientific conclusions, like the inaccurate localization of neural processes, and in practical applications, such as using ERPs as biomarkers in medicine, it may result in incorrect diagnoses or ineffective treatments. In line with the development and advancement of good scientific practice (GSP) in ERP research, this study sought to address several questions regarding the most suitable digital reference for investigating the N400 ERP component.
View Article and Find Full Text PDFClinical case of co-infection: Dengue fever and respiratory mycoplasmosis in a child.
Respir Med Case Rep
December 2024
Central RI [Research Institute] of Epidemiology, Federal Service for the Oversight of Consumer Protection and Welfare (Rospotrebnadzor), Moscow, Russia.
According to WHO, dengue fever (DF) is currently endemic to more than 100 countries in various regions of Africa, America, and Asia; outbreaks have been reported in Europe. In the Russian Federation, there is a much smaller proportion of children among those infected due to the imported nature of the infection. We described a clinical case of imported dengue fever in an adolescent girl in Moscow after a 5-day vacation.
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