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Age estimation through sternal fusion and costal cartilage ossification using MSCT in a Croatian population: model development and application.
Int J Legal Med
January 2025
University Department of Forensic Sciences, University of Split, R. Boškovića 33, Split, 21000, Croatia.
This study aimed to test age-related changes in sternal fusion and sternal-rib cartilage ossification on multi-slice computed tomography (MSCT) images of the Croatian population. The additional aim was to develop models to estimate age and provide an interface for the model's application and validation. This retrospective study was conducted on 144 MSCT images of the sternal region, and the developed models were tested on 36 MSCT images.
View Article and Find Full Text PDFPartial coverage adhesive augmented sternal fixation and stabilization: A biomechanical analysis.
J Biomech
December 2024
Toronto Metropolitan University, Department of Biomedical Engineering, Canada. Electronic address:
Adhesive-augmented sternal fixation (AASF) has been investigated as an alternative to the clinical standard of cerclage wires; however, previous studies have focused on a full adhesive layer across the sternal midline, which acts as a barrier to bone healing. This study used a human cadaveric model to investigate if partial coverage AASF used in combination with wired fixation could provide adequate stability. Median sternotomies were performed on fifteen human cadaveric sterna.
View Article and Find Full Text PDFIL-4 promotes chondrogenesis of bone marrow mesenchymal stem cells and blockade of IL-4Rα retards the endochondral ossification during rat embryonic bone development.
Basic Clin Pharmacol Toxicol
December 2024
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
Article Synopsis
- The study investigates the roles of interleukin-4 (IL-4) and its receptor (IL-4Rα) in bone formation processes like chondrogenic differentiation and ossification during embryonic development.
- Using an anti-IL-4Rα monoclonal antibody, researchers found that IL-4 significantly promotes the differentiation of rat bone marrow mesenchymal stem cells (BMSCs) into cartilage-forming cells (chondrocytes).
- The research revealed that blocking IL-4Rα in pregnant rats led to abnormal fetal bone development, such as incomplete ossification in the sternum and long bones, indicating that IL-4/IL-4Rα signaling is crucial for proper bone development
[Forensic age diagnosis by assessment of sternum ossification processes].
Sud Med Ekspert
August 2024
Bureau of Forensic Medical Expertise of Moscow Healthcare Department, Moscow, Russia.
Objective: To study the sternum ossification processes that take place over time as well as the possibilities of sternum X-rays application to evaluate the age on the modern Russian population in forensic terms.
Material And Methods: Sternum X-rays with fragments of ribs' chondral parts were obtained from 369 male and female corpses aged 12-96 years without pathological and traumatic changes. The X-rays were done in frontal projection.
Revisiting morphology of xiphoid process of the sternum in human: a comprehensive anatomical study.
Surg Radiol Anat
October 2024
Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, 131 S. Robertson St. Suite 1300, New Orleans, LA, 70112, USA.
Article Synopsis
- The xiphoid process (XP) in humans, considered an anatomical variant, was studied to better understand its morphology and cartilage presence.
- A study using twenty embalmed cadaveric sterna revealed that 85% of XPs contained cartilage, classified into four types based on bone and cartilage proportions.
- The findings suggest that previous research may have misjudged the XP's size and emphasizes the importance of recognizing xiphoidal cartilage as a normal anatomical feature.
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