[76Br]Bromodeoxyuridine ([76Br]BrdU) might allow a determination of proliferation in vivo using positron emission tomography (PET), but only with consideration of organ nonspecific radioactivity constituted by [76Br]bromide. A first study assessed the potential of diuretics to eliminate [76Br]bromide. [76Br]Bromide was injected in the vein of rats and different diuretic combinations were given. Urine was collected and radioactivity measured. Torasemide plus sodium chloride gave better 76Br elimination than the other diuretics. In a second experiment, rats were given [76Br]BrdU. After the radioactivity injection, the rats of the treatment group were given torasemide plus NaCl. At 44 h after the radioactivity injection, the radioactivity concentration and the fraction incorporated into DNA were measured in different organs. Using diuretics, the elimination of [76Br]bromide was increased. The radioactivity decreased 30-50% in most of the organs but the highest radioactivity uptake was found in the organs with more active DNA synthesis. This method may facilitate the use of [76Br]BrdU as a tracer for DNA synthesis using PET.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0969-8051(99)00052-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Carbazole-Bismaleimide Based Hyper-Cross-Linked Porous Organic Polymer for Efficient Iodine Capture.
Langmuir
January 2025
Department of Chemical Engineering, Canakkale Onsekiz Mart University,17100 Canakkale, Turkey.
Radioactive iodine, a key waste product of nuclear energy, has been a significant concern among nuclear materials because of its high volatility and its ability to easily enter the human metabolism. Porous materials containing a large number of N-heterocyclic units such as carbazole in the skeletons use as effective adsorbents showing high iodine capture capacities. Herein, a new carbazole-bismaleimide-based hyper-cross-linked porous organic polymer (CzBMI-POP) was successfully prepared from a new tetra-armed carbazole-maleimide monomer (Bis-Cz(BMI)), which contains biscarbazole units and maleimide side groups.
View Article and Find Full Text PDFSynergistic enhancement in ultra-trace thallium(I) removal using the titanium dioxide/biochar composite.
J Environ Manage
January 2025
Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, China. Electronic address:
Thallium (Tl), recognized for its high toxicity, is subject to stringent international regulations regarding its permissible concentrations at ultra-trace levels. In this study, titanium dioxide (TiO) was integrated with potassium (K)-rich biochar to create TiO/biochar (TiO/BC) composites for synergistic enhancement in ultra-trace Tl(I) removal, focusing on achieving concentration below the rigorous local threshold of 0.1 μg/L for drinking water.
View Article and Find Full Text PDFInvestigating the LiO-AlO-BO matrix: A promising approach for immobilizing radioactive waste.
Appl Radiat Isot
January 2025
Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, 81300, Skudai, Johor, Malaysia.
Dealing with radioactive waste, particularly from various industrial processes, poses significant challenges. This paper explores the use of lithium aluminate borate (Li-Al-B) glass matrix as an alternative method for immobilizing radioactive waste, focusing specifically on waste generated in tin smelting industries, known as tin slag. The study primarily concentrates on transforming tin slag, a byproduct abundant in Natural Occurring Radioactive Material (NORM), into a stable and safe form for disposal.
View Article and Find Full Text PDFExperimental and GEANT4 Simulated FEPE of NaI(Tl) Detector for Linear Sources.
Biomed Phys Eng Express
January 2025
Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences, Qau, Islamabad, Islamabad, 44000, PAKISTAN.
The current study investigated the geometry, design and solid angle impacts on full energy peak efficiency (FEPE) of NaI(Tl) detectors for a line source. A line source is fabricated using 99mTc solution filled in a borosilicate glass tube of inner diameter 3 mm, tube wall thickness 2.5 mm and length 12.
View Article and Find Full Text PDFEstimation of natural radioactivity and radiological hazards in river sediments (sand) used as building materials in South Africa.
Isotopes Environ Health Stud
January 2025
School of Chemistry and Physics, University of KwaZulu-Natal, Scottsville, South Africa.
This study presents an investigation into the natural radioactivity levels of U, Th, and K using a thallium-doped sodium iodide (NaI(TI)) detector and associated radiological hazards in river sediments, specifically sand, which serves as a crucial building material in the KwaZulu-Natal Province of South Africa. The assessment aims to provide insights into potential radiological risks posed by the utilization of these sediments in construction activities. The mean activity concentrations of U, Th, and K are 145.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!