AI Article Synopsis
- Glioblastomas are the most common and aggressive type of astrocytic tumor, with the EGFR gene often being amplified in these cases.
- Research on U87E (EGFR-antisense transfected) and U87V (untransfected) glioblastoma cell lines revealed that Bax expression was higher and bcl-2 expression was lower in the transfected cells.
- These findings suggest that manipulating EGFR expression may help reduce the malignancy of glioblastoma by affecting the balance of bcl-2 and Bax proteins.
Article Abstract
Glioblastomas are the most frequent and most malignant astrocytic gliomas. The epidermal growth factor receptor (EGFR) gene is the most frequently amplified and overexpressed in glioblastomas. The expression of bcl-2 and Bax in EGFR-antisense transfected and un-transfected glioblastoma cell line, U87E and U87V was studied by immunohistochemistry and western blotting. Our results show that the expression of Bax was stronger and bcl-2 was weaker in EGFR-antisense transfected cell line than the untransfected control. Bcl-2 and Bax genes are probably involved in the reduction of malignancy of glioblastoma cell caused by the introduction of EGFR-antisense into these tumor cells.
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