The level of urinary excretion of catecholamines (CA) and their precursors was studied in 87 patients with stage I, II hypertensive disease (HD). Three groups were formed depending on the therapy option: group I comprised stage I HD patients in whom endonasal dalargin electrophoresis (EDE) was instituted, groups II and III were patients with stage II HD who were given a complex therapy with captopril plus EDE and monotherapy with captopril respectively. EDE led to a decline in the functional activity of the sympathoadrenal system (SAS) in stage I HD patients and potentiated a hypotensive effect of captopril resulting in diminution of excretion of norepinephrine. Captopril monotherapy failed to have an effect on the SAS condition.
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