The effect of hyperacetylation of histones on the packing of nucleosomal fibers into higher-order structures was studied. The organization of the higher-order levels of packing of hyperacetylated and normal chromatin in intact hepatocytes of green marmoset (CV1 line) was compared by using the intercalating agent chloroquine diphosphate to change the axial twinting of DNA of internucleosomal linkers.
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