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Surgical parathyroidectomy in pregnancy for severe secondary hyperparathyroidism associated with end-stage kidney disease.
BMJ Case Rep
January 2025
Maternity Services, The Royal Women's Hospital, Parkville, Victoria, Australia.
Secondary hyperparathyroidism (SHPT) is common in patients with end-stage kidney disease (ESKD) on kidney replacement therapy, which leads to abnormalities of bone and mineral metabolism. Patients conceiving on kidney replacement therapy add a further layer of complexity to the management of their SHPT. Existing literature in cases of primary hyperparathyroidism (PHPT) has linked untreated hyperparathyroidism to increased maternal and fetal morbidity, including hypertensive disorders of pregnancy, fetal growth restriction and neonatal hypocalcaemia.
View Article and Find Full Text PDFPregnancy Related Acute Kidney Injury: An Exigent Cause of Chronic Kidney Disease in Developing Countries.
J Obstet Gynaecol India
December 2024
Department of Nephrology, SMS Medical College and Hospital, Jaipur, Rajasthan India.
Background: Development of PRAKI due to various gestation-related complication leads to poor maternal and foetal outcome. The aim of this study was to estimate the prevalence of PRAKI resulting in CKD, associated factors and feto-maternal outcome.
Methods: In this prospective observational study patients with PRAKI requiring ≥ 1 session of haemodialysis were included and followed up for 6 months to assess renal outcomes.
Urinary congophilia as a predictive biomarker of lupus nephritis in pregnant and non-pregnant women with systemic lupus erythematosus.
Lupus
January 2025
Mansoura Nephrology and Dialysis Unit, Mansoura University, Mansoura, Egypt.
Background: Endoplasmic reticulum stress with protein misfolding has been introduced as a key pathogenetic mechanism in lupus nephritis (LN). Pregnancy is thought to exaggerate proteostasis, which leads to the accumulation of potentially pathogenic misfolded proteins in the urine, serum, and placenta particularly in women with preeclampsia. The detection of misfolded proteins is made using Congo red stain, which is referred to as congophilia.
View Article and Find Full Text PDFUse of Renal Replacement Therapy in Pregnant Women with Acute Kidney Injury or Chronic Kidney Disease: A Systematic Review.
Acta Med Philipp
October 2024
Faculty of Medicine, Autonomous University of the State of Mexico.
Article Synopsis
- - The text discusses Acute Kidney Injury (AKI) during pregnancy, highlighting its risks and the standard treatment approach, which often involves pregnancy termination followed by conventional AKI treatment.
- - A systematic review was conducted on pregnant women with AKI or chronic kidney disease (CKD) undergoing renal replacement therapy (RRT), analyzing maternal and neonatal health outcomes over the past 30 years using various databases.
- - The review found that out of 1673 women analyzed, 1208 received hemodialysis (HD) and 170 peritoneal dialysis (PD), with a notable survival rate of 74% for fetuses in HD and 40% in PD, indicating that RRT can significantly improve survival rates for
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