While using different methods of skeletal investigation, definite alterations were revealed in frequency of osteosarcomas under plutonium exposure (2.5 muC/Kg). The ratio of the corresponding values is 1:1,2:1,27:1,47. The highest incidence of osteosarcomas was noted in the complex roentgeno-morphological study (according to an extensive scheme of procurement of the osteomaterial) -- 39.8% In separate application of different methods of skeletal investigation the roentgenological method seems to be prefered: it determines more precisely the number of tumor nodes and the number of tumor-bearing rats, accordingly.
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