AI Article Synopsis
- Prolactin (PRL) has been thought to act as the juvenile hormone in anuran tadpoles, counteracting the effects of thyroid hormone (TH) involved in metamorphosis.
- Experiments showed that overexpressing PRL in transgenic X. laevis tadpoles does not extend their lifespan, suggesting PRL does not have a role similar to juvenile hormone in insects.
- However, PRL overexpression leads to the development of tailed frogs by reversing certain processes of tail resorption and promoting fibroblast growth, even in the presence of TH.
Article Abstract
Prolactin (PRL) is widely considered to be the juvenile hormone of anuran tadpoles and to counteract the effects of thyroid hormone (TH), the hormone that controls amphibian metamorphosis. This putative function was concluded mainly from experiments in which mammalian PRL was injected into tadpoles or added to cultured tadpole tissues. In this study, we show that overexpression of ovine or Xenopus laevis PRL in transgenic X. laevis does not prolong tadpole life, establishing that PRL does not play a role in the life cycle of amphibians that is equivalent to that of juvenile hormone in insect metamorphosis. However, overexpression of PRL produces tailed frogs by reversing specifically some but not all of the programs of tail resorption and stimulating growth of fibroblasts in the tail. Whereas TH induces muscle resorption in tails of these transgenics, the tail fibroblasts continue to proliferate resulting in a fibrotic tail that is resistant to TH.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC26639 | PMC |
| http://dx.doi.org/10.1073/pnas.97.1.195 | DOI Listing |
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