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Selective Role of the Putamen in Serial Reversal Learning in the Marmoset.
Cereb Cortex
January 2019
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, UK.
Fronto-striatal circuitry involving the orbitofrontal cortex has been identified as mediating successful reversal of stimulus-outcome contingencies. The region of the striatum that most contributes to reversal learning remains unclear, with studies in primates implicating both caudate nucleus and putamen. We trained four marmosets on a touchscreen-based serial reversal task and implanted each with cannulae targeting both putamen and caudate bilaterally.
View Article and Find Full Text PDFSchizophrenia alters intra-network functional connectivity in the caudate for detecting speech under informational speech masking conditions.
BMC Psychiatry
April 2018
School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Key Laboratory on Machine Perception (Ministry of Education), Peking University, 5 Yiheyuan Road, Beijing, 100080, People's Republic of China.
Background: Speech recognition under noisy "cocktail-party" environments involves multiple perceptual/cognitive processes, including target detection, selective attention, irrelevant signal inhibition, sensory/working memory, and speech production. Compared to health listeners, people with schizophrenia are more vulnerable to masking stimuli and perform worse in speech recognition under speech-on-speech masking conditions. Although the schizophrenia-related speech-recognition impairment under "cocktail-party" conditions is associated with deficits of various perceptual/cognitive processes, it is crucial to know whether the brain substrates critically underlying speech detection against informational speech masking are impaired in people with schizophrenia.
View Article and Find Full Text PDFIncreased drinking after intra-striatal injection of the dopamine D2/D3 receptor agonist quinpirole in the rat.
Psychopharmacology (Berl)
October 2012
Section of Addiction Medicine, Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Rationale: Dopamine D2 receptor hyperactivity has been implicated in the development of psychogenic polydipsia in schizophrenic patients. Repeated treatment with dopamine agonists, including the D2/D3 agonist quinpirole, has been shown to induce hyperdipsia in a number of animal models. Despite these observations, obtained with systemic administrations, little attempt has been made to investigate where in the brain dopamine agonists act to induce hyperdipsia.
View Article and Find Full Text PDF[Role of nitric oxide in excitotoxicity and memory impairment induced by kainic acid].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
June 2000
Department of Physiology, Institute of Basic Medical Sciences, CAMS, PUMC, Beijing 100005, China.
Objective: The role of nitric oxide (NO) in excitotoxicity of kainic acid (KA) in the brain was investigated.
Methods: Adult female rats were bilaterally intra-caudate nucleus injected with KA. The nitric oxide synthase (NOS) was determined by measuring NO2- concentration produced from homogenized brain tissue in the enzyme response system at three time point after surgery.
Distinct inhibition of acute cocaine-stimulated motor activity following microinjection of a group III metabotropic glutamate receptor agonist into the dorsal striatum of rats.
Pharmacol Biochem Behav
September 2000
Division of Pharmacology, School of Pharmacy, University of Missouri-Kansas City, 2411 Holmes Street, M3-C15, Kansas City, MO 64108-2792, USA.
Group III metabotropic glutamate receptors (mGluRs) are negatively coupled to adenylate cyclase through G-proteins. Activation of this group of mGluRs shows an inhibition of dopaminergic transmission in the forebrain. To define the role of striatal group III mGluRs in the regulation of basal and dopamine-stimulated motor behavior, the recently developed agonist and antagonist relatively selective for group III mGluRs were utilized to pharmacologically enhance and reduce group III mGluR glutamatergic tone in the dorsal striatum of chronically cannulated rats.
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